Advances in predicting venous thromboembolism risk in children

Frank Ruhle*, Monika Stoll

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

12 Citations (Web of Science)

Abstract

Paediatric venous thromboembolism (VTE) is a rare disorder but a rising incidence has been observed in recent years, due to improved VTE diagnosis and increased use of central venous catheters in the treatment of severe diseases. Risk assessment strategies are well established for adult patients, however, similar guidelines for paediatric patients are largely lacking. Several risk prediction tools have been reported in recent literature, which make use of established risk factors to assess VTE risk in paediatric subgroups, such as hospitalised children, cancer-diagnosed children and paediatric trauma patients. Although these models suffer several limitations regarding their study size and heterogeneous selection of predictor variables, they offer potential for improving the thromboprophylaxis management in these children. Here, we give an overview on recently reported risk prediction models for paediatric VTE.
Original languageEnglish
Pages (from-to)654-665
Number of pages12
JournalBritish Journal of Haematology
Volume180
Issue number5
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • paediatric VTE
  • thrombosis
  • thrombophilia
  • risk factor
  • prediction modelling
  • risk score
  • FACTOR-V-LEIDEN
  • PEDIATRIC TRAUMA PATIENTS
  • ARTERIAL ISCHEMIC-STROKE
  • HUMAN COAGULATION SYSTEM
  • CRITICALLY-ILL CHILDREN
  • DEEP-VEIN THROMBOSIS
  • DEVELOPMENTAL HEMOSTASIS
  • LABORATORY CHARACTERISTICS
  • COMMON MTHFR
  • PROTEIN-C

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