Advances in Chlamydia trachomatis Vaccination: Unveiling the Potential of Major Outer Membrane Protein Derivative Constructs

Celien Kiekens, Servaas A Morré, Daisy Vanrompay*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

( ) , a leading cause of sexually transmitted infections (STIs) worldwide, continues to be a significant public health concern. The majority of infections are asymptomatic and, when left untreated, severe sequelae such as infertility and chronic pelvic pain can occur. Despite decades of research, an effective vaccine remains elusive. This review focuses on the potential of Major Outer Membrane Protein (MOMP)-derived constructs as promising candidates for vaccination. MOMP, the most abundant protein in the outer membrane of , has been a focal point of vaccine research over the years due to its antigenic properties. To overcome issues associated with the use of full MOMP as a vaccine antigen, derivative constructs have been studied. As these constructs are often not sufficiently immunogenic, antigen delivery systems or accompanying adjuvants are required. Additionally, several immunization routes have been explored with these MOMP-derived vaccine antigens, and determining the optimal route remains an ongoing area of research. Future directions and challenges in the field of vaccination are discussed.
Original languageEnglish
Article number1196
Number of pages20
JournalMicroorganisms
Volume12
Issue number6
DOIs
Publication statusPublished - 13 Jun 2024

Keywords

  • Chlamydia trachomatis
  • MOMP
  • STI
  • subunit vaccines
  • vaccination

Fingerprint

Dive into the research topics of 'Advances in Chlamydia trachomatis Vaccination: Unveiling the Potential of Major Outer Membrane Protein Derivative Constructs'. Together they form a unique fingerprint.

Cite this