Advanced microscopy techniques for quantitative analysis in neuromorphology and neuropathology research: current status and requirements for the future

Marijke A. M. Lemmens*, Harry W. M. Steinbusch, Bart P. F. Rutten, Christoph Schmitz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Web of Science)


Visualizing neuromorphology and in particular neuropathology has been the focus of many researchers in the quest to solve the numerous questions that are still remaining related to several neurological and neuropsychiatric diseases. Over the last years, intense research into microscopy techniques has resulted in the development of various new types of microscopes, software imaging systems, and analysis programs. This review briefly discusses some key techniques, such as confocal stereology and automated neuron tracing and reconstruction, and their applications in neuroscience research. Special emphasis is placed on needs for further developments, such as the demand for higher-throughput analyses in quantitative neuromorphology. These developments will advance basic neuroscience research as well as pharmaceutical and biotechnology research and development.
Original languageEnglish
Pages (from-to)199-209
JournalJournal of Chemical Neuroanatomy
Issue number3
Publication statusPublished - Nov 2010


  • Neuropathology
  • Neuromorphology
  • Tracing
  • Stereology
  • Microscopy

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