Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index.

D. Stolz, K. Kostikas, F. Blasi, W. Boersma, B. Milenkovic, A. Lacoma, R. Louis, J.G. Aerts, T. Welte, A. Torres, G.G. Rohde, L. Boeck, J. Rakic, A. Scherr, S. Hertel, S. Giersdorf, M. Tamm

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Abstract

The BODE index is well-validated for mortality prediction in COPD. of plasma proadrenomedullin, a surrogate for mature adrenomedullin, predicted 2-year mortality among inpatients with COPD exacerbation.We accuracy of initial proadrenomedullin level, BODE, and BODE components, combined, in predicting 1-year or 2-year all-cause mortality in a multinational observational cohort with stable, moderate to very severe COPD.Proadrenomedullin was significantly associated (P<0.001) with 1- mortality (4.7%) and 2-year mortality (7.8%), and comparably predictive regarding both (C statistics: 0.691 vs. 0.745, 0.635 vs. 0.679). using BODE alone, adding proadrenomedullin significantly improved 1-year 2-year mortality prognostication (C statistics: 0.750, 0.818; both Proadrenomedullin plus BOD was more predictive than was the original including 6-minute-walk distance. In multivariable analysis, (LR X2 13.0, P<0.001), body mass index (8.5, P=0.004), and 6-minute-walk (7.5, P=0.006), but not modified MMRC dyspnoea score (2.2, P=0.14) or predicted (0.3, P=0.60), independently foretold 2-year plus BODE better predicts mortality in COPD patients than does BODE proadrenomedullin may substitute for 6-minute-walk distance in BODE when 6-minute-walk testing is unavailable.
Original languageEnglish
Pages (from-to)397-408
JournalEuropean Respiratory Journal
Volume43
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014

Cite this

Stolz, D., Kostikas, K., Blasi, F., Boersma, W., Milenkovic, B., Lacoma, A., Louis, R., Aerts, J. G., Welte, T., Torres, A., Rohde, G. G., Boeck, L., Rakic, J., Scherr, A., Hertel, S., Giersdorf, S., & Tamm, M. (2014). Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index. European Respiratory Journal, 43(2), 397-408. https://doi.org/10.1183/09031936.00058713