TY - JOUR
T1 - Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations for cancer prevention is associated with better health-related quality of life among long-term colorectal cancer survivors
T2 - results of the PROFILES registry
AU - van Veen, Merel R.
AU - Mols, Floortje
AU - Bours, Martijn J. L.
AU - Weijenberg, Matty P.
AU - Kampman, Ellen
AU - Beijer, Sandra
N1 - Funding Information:
The authors thank the registration teams of the Netherlands Comprehensive Cancer Organisation for the collection of data for the Netherlands Cancer Registry and members of the PROFILES registry for distribution and handling of the questionnaires. We are very grateful for the participation of all patients and their doctors in the study. Special thanks go to Dr. M. van Bommel, who was willing to function as an independent advisor and to answer questions of patients. We also want to thank the following hospitals for their cooperation: Amphia hospital, Breda; Bernhoven Hospital, Uden; Catharina hospital, Eindhoven; Elisabeth-TweeSteden hospital, Tilburg and Waalwijk; Elkerliek Hospital, Helmond; Jeroen Bosch hospital, ‘s Hertogenbosch; Maxima Medical Centre, Eindhoven and Veldhoven; Sint Anna hospital, Geldrop; VieCury hospital, Venlo and Venray.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12
Y1 - 2019/12
N2 - Since colorectal cancer (CRC) survivors often suffer from long-term adverse health effects of the cancer and its treatment, having a negative impact on their health-related quality of life (HRQL), this study focuses on the association between adherence to WCRF/AICR recommendations and HRQL among CRC survivors. In a cross-sectional PROFILES registry study in 1096 CRC survivors (mean time since diagnosis 8.1 years), WCRF/AICR adherence scores (range 0-8, with a higher score for better adherence) were calculated, and HRQL was assessed using the EORTC QLQ-C30. Associations between adherence scores and HRQL scores were investigated using linear regression analyses. Additionally, associations with adherence to guidelines for body mass index (BMI) (normal weight, overweight and obese), physical activity (PA) (score 0/1) and diet (score <3, 3- <4 and > 4) were evaluated separately. Mean adherence score was 4.81 +/- 1.04. Higher WCRF/AICR scores were associated with better global health status (beta 1.64; 95%CI 0.69/2.59), physical functioning (beta 2.71; 95%CI 1.73/3.68), role functioning (beta 2.87; 95%CI 1.53/4.21), cognitive functioning (beta 1.25; 95%CI 0.19/2.32), social functioning (beta 2.01; 95%CI 0.85/3.16) and fatigue (beta - 2.81; 95%CI - 4.02/- 1.60). Adherence versus non-adherence PA was significantly associated with better physical, role, emotional and social functioning, global health status and less fatigue. Except for the association between being obese and physical functioning (beta - 4.15; 95%CI - 47.16/- 1.15), no statistically significant associations with physical functioning were observed comparing adherence to non-adherence to BMI and dietary recommendations. Better adherence to the WCRF/AICR recommendations was positively associated with global health status, most functioning scales and less fatigue among CRC survivors. PA seemed to be the main contributor.
AB - Since colorectal cancer (CRC) survivors often suffer from long-term adverse health effects of the cancer and its treatment, having a negative impact on their health-related quality of life (HRQL), this study focuses on the association between adherence to WCRF/AICR recommendations and HRQL among CRC survivors. In a cross-sectional PROFILES registry study in 1096 CRC survivors (mean time since diagnosis 8.1 years), WCRF/AICR adherence scores (range 0-8, with a higher score for better adherence) were calculated, and HRQL was assessed using the EORTC QLQ-C30. Associations between adherence scores and HRQL scores were investigated using linear regression analyses. Additionally, associations with adherence to guidelines for body mass index (BMI) (normal weight, overweight and obese), physical activity (PA) (score 0/1) and diet (score <3, 3- <4 and > 4) were evaluated separately. Mean adherence score was 4.81 +/- 1.04. Higher WCRF/AICR scores were associated with better global health status (beta 1.64; 95%CI 0.69/2.59), physical functioning (beta 2.71; 95%CI 1.73/3.68), role functioning (beta 2.87; 95%CI 1.53/4.21), cognitive functioning (beta 1.25; 95%CI 0.19/2.32), social functioning (beta 2.01; 95%CI 0.85/3.16) and fatigue (beta - 2.81; 95%CI - 4.02/- 1.60). Adherence versus non-adherence PA was significantly associated with better physical, role, emotional and social functioning, global health status and less fatigue. Except for the association between being obese and physical functioning (beta - 4.15; 95%CI - 47.16/- 1.15), no statistically significant associations with physical functioning were observed comparing adherence to non-adherence to BMI and dietary recommendations. Better adherence to the WCRF/AICR recommendations was positively associated with global health status, most functioning scales and less fatigue among CRC survivors. PA seemed to be the main contributor.
KW - Colorectal cancer survivors
KW - Health-related quality of life
KW - WCRF guidelines
KW - Dietary guidelines
KW - Physical activity
KW - Body composition
KW - STYLE FACTORS
KW - EXERCISE
KW - BREAST
KW - DIET
KW - INSTRUMENT
KW - GUIDELINES
KW - PROSTATE
KW - FATIGUE
KW - FRUIT
KW - RISK
U2 - 10.1007/s00520-019-04735-y
DO - 10.1007/s00520-019-04735-y
M3 - Article
C2 - 30927111
SN - 0941-4355
VL - 27
SP - 4565
EP - 4574
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 12
ER -