Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study

Cora Wunder; Alexandre Persu; Jean-Philippe Lengele; Coralie M. G. Georges; Jean Renkin; Agnes Pasquet; Marc Carlier; Zhen-Yu Zhang; Jan A. Staessen; Stefan W. Toennes; The European Network Coordinating Research on Renal Denervation (ENCOReD)

doi:10.1080/08037051.2019.1599814

Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study

Cora Wunder^*, Alexandre Persu, Jean-Philippe Lengele, Coralie M. G. Georges, Jean Renkin, Agnes Pasquet, Marc Carlier, Zhen-Yu Zhang, Jan A. Staessen, Stefan W. Toennes, The European Network Coordinating Research on Renal Denervation (ENCOReD)

^*Corresponding author for this work

Carim - Hypertension and target organ damage

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods.Materials and methods: The current analysis included patients with apparently treatment- resistant hypertension (TRH) referred for renal denervation (RDN) and included in the the INSPiRED pilot trial (NCT 01505010). Adherence was repeatedly assessed by toxicological urine analysis over a time range of up to 17 months in a total of 18 patients.Results: In the first urine samples of 18 patients the adherence rate (percentage of number of detected vs. prescribed medical drugs) ranged from 0 to 100% with a median of 73.2%. In further urine samples collected during the following up to 17 months every individual patient exhibited considerable changes in the adherence rate, neither a constancy nor a tendency could be deduced.Conclusions: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time.

Original language	English
Pages (from-to)	168-172
Number of pages	5
Journal	Blood Pressure
Volume	28
Issue number	3
DOIs	https://doi.org/10.1080/08037051.2019.1599814
Publication status	Published - 2019

Keywords

Compliance
resistant hypertension
toxicological analysis
antihypertensive drugs
renal denervation
INTRAVASCULAR RENAL DENERVATION
MEDICATION ADHERENCE
NONADHERENCE
MANAGEMENT
THERAPY

Access to Document

10.1080/08037051.2019.1599814

Cite this

Wunder, C., Persu, A., Lengele, J.-P., Georges, C. M. G., Renkin, J., Pasquet, A., Carlier, M., Zhang, Z.-Y., Staessen, J. A., Toennes, S. W., & The European Network Coordinating Research on Renal Denervation (ENCOReD) (2019). Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study. Blood Pressure, 28(3), 168-172. https://doi.org/10.1080/08037051.2019.1599814

@article{aa29c6b083c6451db00addfd0efa872f,

title = "Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study",

abstract = "Purpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods.Materials and methods: The current analysis included patients with apparently treatment- resistant hypertension (TRH) referred for renal denervation (RDN) and included in the the INSPiRED pilot trial (NCT 01505010). Adherence was repeatedly assessed by toxicological urine analysis over a time range of up to 17 months in a total of 18 patients.Results: In the first urine samples of 18 patients the adherence rate (percentage of number of detected vs. prescribed medical drugs) ranged from 0 to 100% with a median of 73.2%. In further urine samples collected during the following up to 17 months every individual patient exhibited considerable changes in the adherence rate, neither a constancy nor a tendency could be deduced.Conclusions: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time.",

keywords = "Compliance, resistant hypertension, toxicological analysis, antihypertensive drugs, renal denervation, INTRAVASCULAR RENAL DENERVATION, MEDICATION ADHERENCE, NONADHERENCE, MANAGEMENT, THERAPY",

author = "Cora Wunder and Alexandre Persu and Jean-Philippe Lengele and Georges, {Coralie M. G.} and Jean Renkin and Agnes Pasquet and Marc Carlier and Zhen-Yu Zhang and Staessen, {Jan A.} and Toennes, {Stefan W.} and {The European Network Coordinating Research on Renal Denervation (ENCOReD)}",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2019",

doi = "10.1080/08037051.2019.1599814",

language = "English",

volume = "28",

pages = "168--172",

journal = "Blood Pressure",

issn = "0803-7051",

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Wunder, C, Persu, A, Lengele, J-P, Georges, CMG, Renkin, J, Pasquet, A, Carlier, M, Zhang, Z-Y, Staessen, JA, Toennes, SW & The European Network Coordinating Research on Renal Denervation (ENCOReD) 2019, 'Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study', Blood Pressure, vol. 28, no. 3, pp. 168-172. https://doi.org/10.1080/08037051.2019.1599814

TY - JOUR

T1 - Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study

AU - Wunder, Cora

AU - Persu, Alexandre

AU - Lengele, Jean-Philippe

AU - Georges, Coralie M. G.

AU - Renkin, Jean

AU - Pasquet, Agnes

AU - Carlier, Marc

AU - Zhang, Zhen-Yu

AU - Staessen, Jan A.

AU - Toennes, Stefan W.

AU - The European Network Coordinating Research on Renal Denervation (ENCOReD)

PY - 2019

Y1 - 2019

N2 - Purpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods.Materials and methods: The current analysis included patients with apparently treatment- resistant hypertension (TRH) referred for renal denervation (RDN) and included in the the INSPiRED pilot trial (NCT 01505010). Adherence was repeatedly assessed by toxicological urine analysis over a time range of up to 17 months in a total of 18 patients.Results: In the first urine samples of 18 patients the adherence rate (percentage of number of detected vs. prescribed medical drugs) ranged from 0 to 100% with a median of 73.2%. In further urine samples collected during the following up to 17 months every individual patient exhibited considerable changes in the adherence rate, neither a constancy nor a tendency could be deduced.Conclusions: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time.

AB - Purpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods.Materials and methods: The current analysis included patients with apparently treatment- resistant hypertension (TRH) referred for renal denervation (RDN) and included in the the INSPiRED pilot trial (NCT 01505010). Adherence was repeatedly assessed by toxicological urine analysis over a time range of up to 17 months in a total of 18 patients.Results: In the first urine samples of 18 patients the adherence rate (percentage of number of detected vs. prescribed medical drugs) ranged from 0 to 100% with a median of 73.2%. In further urine samples collected during the following up to 17 months every individual patient exhibited considerable changes in the adherence rate, neither a constancy nor a tendency could be deduced.Conclusions: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time.

KW - Compliance

KW - resistant hypertension

KW - toxicological analysis

KW - antihypertensive drugs

KW - renal denervation

KW - INTRAVASCULAR RENAL DENERVATION

KW - MEDICATION ADHERENCE

KW - NONADHERENCE

KW - MANAGEMENT

KW - THERAPY

U2 - 10.1080/08037051.2019.1599814

DO - 10.1080/08037051.2019.1599814

M3 - Article

C2 - 30942111

SN - 0803-7051

VL - 28

SP - 168

EP - 172

JO - Blood Pressure

JF - Blood Pressure

IS - 3

ER -