Adherence improvement in Dutch glaucoma patients: a randomized controlled trial

Henny J. M. Beckers*, Carroll A. B. Webers, Michiel J. W. M. Busch, Hendrik M. A. Brink, Thomas P. Colen, Jan S. A. G. Schouten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose: To study the effect of patient education and the TravAlert((R))-Eyot((R)) drop guider on intraocular pressure (IOP) and adherence in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT) monitored with the TravAlert((R)) dosing aid. Methods: Multicentre, randomized, controlled clinical trial among 18 Dutch hospitals. Patients were randomized to one of the four study arms: (1) use of the dosing aid, (2) use of the dosing aid with the drop guider, (3) use of the dosing aid together with patient education or (4) use of the dosing aid and drop guider together with patient education. IOP was recorded at baseline and after 3 and 6months. Data on adherence generated by the dosing aid were collected and studied at the end of the study. Results: Mean IOP dropped from 20.35.7mmHg at baseline to 16.3 +/- 4.0mmHg (right eye) after 6months and from 20.2 +/- 5.9mmHg to 16.4 +/- 4.1mmHg (left eye). The mean adherence rate was 0.91 +/- 0.1. IOP and adherence rate were not statistically different between the study arms. Patients with drug holidays' had a significantly higher mean IOP after 6months. Patients who used the drop guider were less adherent. A lower adherence level was also associated with new patients with glaucoma and patients with a lower level of knowledge on glaucoma. Conclusion: Patient education is especially useful for new patients with glaucoma. The use of a drop guider does not improve adherence. Especially patients with drug holidays' are at risk for developing uncontrolled IOP levels.
Original languageEnglish
Pages (from-to)610-618
JournalActa Ophthalmologica
Issue number7
Publication statusPublished - Nov 2013


  • Glaucoma
  • adherence
  • electronic monitoring
  • patient education
  • drop guider


Dive into the research topics of 'Adherence improvement in Dutch glaucoma patients: a randomized controlled trial'. Together they form a unique fingerprint.

Cite this