Additive Value of Semiautomated Quantification of Coronary Artery Disease Using Cardiac Computed Tomographic Angiography to Predict Future Acute Coronary Syndrome

Mathijs O. Versteylen*, Bas L. Kietselaer, Pieter C. Dagnelie, Ivo A. Joosen, Admir Dedic, Rolf H. Raaijmakers, Joachim E. Wildberger, Koen Nieman, Harry J. Crijns, Wiro J. Niessen, Mat J. Daemen, Leonard Hofstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

127 Citations (Web of Science)


Objectives The purpose of this study was to investigate whether the use of a semiautomated plaque quantification algorithm (reporting volumetric and geometric plaque properties) provides additional prognostic value for the development of acute coronary syndromes (ACS) as compared with conventional reading from cardiac computed tomography angiography (CCTA). Background CCTA enables the visualization of coronary plaque characteristics, of which some have been shown to predict ACS. Methods A total of 1,650 patients underwent 64-slice CCTA and were followed up for ACS for a mean 26 +/- 10 months. In 25 patients who had ACS and 101 random controls (selected from 993 patients with coronary artery disease but without coronary event), coronary artery disease was evaluated using conventional reading (calcium score, luminal stenosis, morphology), and then independently quantified using semiautomated software (plaque volume, burden area [plaque area divided by vessel area times 100%], noncalcified percentage, attenuation, remodeling). Clinical risk profile was calculated with Framingham risk score (FRS). Results There were no significant differences in conventional reading parameters between controls and patients who had ACS. Semiautomated plaque quantification showed that compared to controls, ACS patients had higher total plaque volume (median: 94 mm(3) vs. 29 mm(3)) and total noncalcified volume (28 mm(3) vs. 4 mm(3), p
Original languageEnglish
Pages (from-to)2296-2305
JournalJournal of the American College of Cardiology
Issue number22
Publication statusPublished - 4 Jun 2013


  • acute coronary syndrome(s)
  • cardiac computed tomography angiography
  • plaque characteristics quantification
  • prognostic value

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