Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study

Oliver J. Gurney-Champion; Eva Versteijne; Astrid van der Horst; Eelco Lens; Heidi Ruetten; Hanne D. Heerkens; Gabriel M. R. M. Paardekooper; Maaike Berbee; Coen R. N. Rasch; Jaap Stoker; Marc R. W. Engelbrecht; Marcel van Herk; Aart J. Nederveen; Remy Klaassen; Hanneke W. M. van Laarhoven; Geertjan van Tienhoven; Arjan Bel

doi:10.1080/0284186X.2017.1304654

Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study

Oliver J. Gurney-Champion^*, Eva Versteijne, Astrid van der Horst, Eelco Lens, Heidi Ruetten, Hanne D. Heerkens, Gabriel M. R. M. Paardekooper, Maaike Berbee, Coen R. N. Rasch, Jaap Stoker, Marc R. W. Engelbrecht, Marcel van Herk, Aart J. Nederveen, Remy Klaassen, Hanneke W. M. van Laarhoven, Geertjan van Tienhoven, Arjan Bel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Web of Science)

Abstract

Purpose: To assess the effect of additional magnetic resonance imaging (MRI) alongside the planning computed tomography (CT) scan on target volume delineation in pancreatic cancer patients.Material and methods: Eight observers (radiation oncologists) from six institutions delineated the gross tumor volume (GTV) on 3DCT, and internal GTV (iGTV) on 4DCT of four pancreatic cancer patients, while MRI was available in a second window (CT+MRI). Variations in volume, generalized conformity index (CIgen), and overall observer variation, expressed as standard deviation (SD) of the distances between delineated surfaces, were analyzed. CIgen is a measure of overlap of the delineated iGTVs (1=full overlap, 0=no overlap). Results were compared with those from an earlier study that assessed the interobserver variation by the same observers on the same patients on CT without MRI (CT-only).Results: The maximum ratios between delineated volumes within a patient were 6.1 and 22.4 for the GTV (3DCT) and iGTV (4DCT), respectively. The average (root-mean-square) overall observer variations were SD=0.41cm (GTV) and SD=0.73cm (iGTV). The mean CIgen was 0.36 for GTV and 0.37 for iGTV. When compared to the iGTV delineated on CT-only, the mean volumes of the iGTV on CT+MRI were significantly smaller (32%, Wilcoxon signed-rank, p

Original language	English
Pages (from-to)	923-930
Number of pages	8
Journal	Acta Oncologica
Volume	56
Issue number	7
DOIs	https://doi.org/10.1080/0284186X.2017.1304654
Publication status	Published - 2017

Keywords

TARGET VOLUME DELINEATION
RADIATION-THERAPY
INTRATUMORAL FIDUCIALS
OBSERVER VARIATION
QUALITY-ASSURANCE
CANCER ANALYSIS
SCALOP TRIAL
RADIOTHERAPY
VARIABILITY
MARKERS

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10.1080/0284186X.2017.1304654

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Gurney-Champion, O. J., Versteijne, E., van der Horst, A., Lens, E., Ruetten, H., Heerkens, H. D., Paardekooper, G. M. R. M., Berbee, M., Rasch, C. R. N., Stoker, J., Engelbrecht, M. R. W., van Herk, M., Nederveen, A. J., Klaassen, R., van Laarhoven, H. W. M., van Tienhoven, G., & Bel, A. (2017). Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study. Acta Oncologica, 56(7), 923-930. https://doi.org/10.1080/0284186X.2017.1304654

@article{39af2269d54f48aeb172115c45859667,

title = "Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study",

abstract = "Purpose: To assess the effect of additional magnetic resonance imaging (MRI) alongside the planning computed tomography (CT) scan on target volume delineation in pancreatic cancer patients.Material and methods: Eight observers (radiation oncologists) from six institutions delineated the gross tumor volume (GTV) on 3DCT, and internal GTV (iGTV) on 4DCT of four pancreatic cancer patients, while MRI was available in a second window (CT+MRI). Variations in volume, generalized conformity index (CIgen), and overall observer variation, expressed as standard deviation (SD) of the distances between delineated surfaces, were analyzed. CIgen is a measure of overlap of the delineated iGTVs (1=full overlap, 0=no overlap). Results were compared with those from an earlier study that assessed the interobserver variation by the same observers on the same patients on CT without MRI (CT-only).Results: The maximum ratios between delineated volumes within a patient were 6.1 and 22.4 for the GTV (3DCT) and iGTV (4DCT), respectively. The average (root-mean-square) overall observer variations were SD=0.41cm (GTV) and SD=0.73cm (iGTV). The mean CIgen was 0.36 for GTV and 0.37 for iGTV. When compared to the iGTV delineated on CT-only, the mean volumes of the iGTV on CT+MRI were significantly smaller (32%, Wilcoxon signed-rank, p",

keywords = "TARGET VOLUME DELINEATION, RADIATION-THERAPY, INTRATUMORAL FIDUCIALS, OBSERVER VARIATION, QUALITY-ASSURANCE, CANCER ANALYSIS, SCALOP TRIAL, RADIOTHERAPY, VARIABILITY, MARKERS",

author = "Gurney-Champion, {Oliver J.} and Eva Versteijne and {van der Horst}, Astrid and Eelco Lens and Heidi Ruetten and Heerkens, {Hanne D.} and Paardekooper, {Gabriel M. R. M.} and Maaike Berbee and Rasch, {Coen R. N.} and Jaap Stoker and Engelbrecht, {Marc R. W.} and {van Herk}, Marcel and Nederveen, {Aart J.} and Remy Klaassen and {van Laarhoven}, {Hanneke W. M.} and {van Tienhoven}, Geertjan and Arjan Bel",

year = "2017",

doi = "10.1080/0284186X.2017.1304654",

language = "English",

volume = "56",

pages = "923--930",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Routledge/Taylor & Francis Group",

number = "7",

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Gurney-Champion, OJ, Versteijne, E, van der Horst, A, Lens, E, Ruetten, H, Heerkens, HD, Paardekooper, GMRM, Berbee, M, Rasch, CRN, Stoker, J, Engelbrecht, MRW, van Herk, M, Nederveen, AJ, Klaassen, R, van Laarhoven, HWM, van Tienhoven, G & Bel, A 2017, 'Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study', Acta Oncologica, vol. 56, no. 7, pp. 923-930. https://doi.org/10.1080/0284186X.2017.1304654

TY - JOUR

T1 - Addition of MRI for CT-based pancreatic tumor delineation

T2 - a feasibility study

AU - Gurney-Champion, Oliver J.

AU - Versteijne, Eva

AU - van der Horst, Astrid

AU - Lens, Eelco

AU - Ruetten, Heidi

AU - Heerkens, Hanne D.

AU - Paardekooper, Gabriel M. R. M.

AU - Berbee, Maaike

AU - Rasch, Coen R. N.

AU - Stoker, Jaap

AU - Engelbrecht, Marc R. W.

AU - van Herk, Marcel

AU - Nederveen, Aart J.

AU - Klaassen, Remy

AU - van Laarhoven, Hanneke W. M.

AU - van Tienhoven, Geertjan

AU - Bel, Arjan

PY - 2017

Y1 - 2017

N2 - Purpose: To assess the effect of additional magnetic resonance imaging (MRI) alongside the planning computed tomography (CT) scan on target volume delineation in pancreatic cancer patients.Material and methods: Eight observers (radiation oncologists) from six institutions delineated the gross tumor volume (GTV) on 3DCT, and internal GTV (iGTV) on 4DCT of four pancreatic cancer patients, while MRI was available in a second window (CT+MRI). Variations in volume, generalized conformity index (CIgen), and overall observer variation, expressed as standard deviation (SD) of the distances between delineated surfaces, were analyzed. CIgen is a measure of overlap of the delineated iGTVs (1=full overlap, 0=no overlap). Results were compared with those from an earlier study that assessed the interobserver variation by the same observers on the same patients on CT without MRI (CT-only).Results: The maximum ratios between delineated volumes within a patient were 6.1 and 22.4 for the GTV (3DCT) and iGTV (4DCT), respectively. The average (root-mean-square) overall observer variations were SD=0.41cm (GTV) and SD=0.73cm (iGTV). The mean CIgen was 0.36 for GTV and 0.37 for iGTV. When compared to the iGTV delineated on CT-only, the mean volumes of the iGTV on CT+MRI were significantly smaller (32%, Wilcoxon signed-rank, p

AB - Purpose: To assess the effect of additional magnetic resonance imaging (MRI) alongside the planning computed tomography (CT) scan on target volume delineation in pancreatic cancer patients.Material and methods: Eight observers (radiation oncologists) from six institutions delineated the gross tumor volume (GTV) on 3DCT, and internal GTV (iGTV) on 4DCT of four pancreatic cancer patients, while MRI was available in a second window (CT+MRI). Variations in volume, generalized conformity index (CIgen), and overall observer variation, expressed as standard deviation (SD) of the distances between delineated surfaces, were analyzed. CIgen is a measure of overlap of the delineated iGTVs (1=full overlap, 0=no overlap). Results were compared with those from an earlier study that assessed the interobserver variation by the same observers on the same patients on CT without MRI (CT-only).Results: The maximum ratios between delineated volumes within a patient were 6.1 and 22.4 for the GTV (3DCT) and iGTV (4DCT), respectively. The average (root-mean-square) overall observer variations were SD=0.41cm (GTV) and SD=0.73cm (iGTV). The mean CIgen was 0.36 for GTV and 0.37 for iGTV. When compared to the iGTV delineated on CT-only, the mean volumes of the iGTV on CT+MRI were significantly smaller (32%, Wilcoxon signed-rank, p

KW - TARGET VOLUME DELINEATION

KW - RADIATION-THERAPY

KW - INTRATUMORAL FIDUCIALS

KW - OBSERVER VARIATION

KW - QUALITY-ASSURANCE

KW - CANCER ANALYSIS

KW - SCALOP TRIAL

KW - RADIOTHERAPY

KW - VARIABILITY

KW - MARKERS

U2 - 10.1080/0284186X.2017.1304654

DO - 10.1080/0284186X.2017.1304654

M3 - Article

C2 - 28375667

VL - 56

SP - 923

EP - 930

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 7

ER -