ADAM17 controls IL-6 signaling by cleavage of the murine IL-6R alpha from the cell surface of leukocytes during inflammatory responses

Isabell Yan, Jeanette Schwarz, Karsten Luecke, Neele Schumacher, Valea Schumacher, Stefanie Schmidt, Bjoern Rabe, Paul Saftig, Marjo Donners, Stefan Rose-John, Hans-Willi Mittruecker, Athena Chalaris*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Web of Science)
Original languageEnglish
Pages (from-to)749-760
JournalJournal of Leukocyte Biology
Issue number5
Publication statusPublished - May 2016


  • Metalloproteases
  • shedding
  • Listeria monocytogenes
  • endotoxin shock
  • trans-signalling

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