TY - JOUR
T1 - Acylated pregnane glycosides from Caralluma quadrangula
AU - Abdallah, Hossam M.
AU - Osman, Abdel-Moneim M.
AU - Almehdar, Hussein
AU - Abdel-Sattar, Essam
PY - 2013/4
Y1 - 2013/4
N2 - In a previous study, the methanolic extract as well as the chloroform fraction of the aerial parts of Caralluma quadrangula (Forssk.) N.E.Br. indigenous to Saudi Arabia showed significant in vitro cytotoxic activity against breast cancer (MCF7) cell line. In a biologically-guided fractionation approach, four acylated pregnane glycosides were isolated from the chloroform fraction of C. quadrangula. The structures of the isolated compounds were elucidated by the analysis of their MS and NMR data. The compounds were identified as 12,20-di-O-benzoylboucerin 3-O-?-D-digitoxopyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (1), 12,20-di-O-benzoylboucerin 3-O-?-D-cymaropyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (2), 12,20-di-O-benzoylboucerin 3-O-?-D-glucopyranosyl-(1?4)-?-D-digitoxopyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (3) and 12,20-di-O-benzoyl-3?,5?,12?,14?,20-pentahydroxy-(20R)-pregn-6-ene 3-O-?-D-glucopyranosyl-(1?4)-?-D-digitoxopyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (4). The isolated compounds were tested for their cytotoxic activity against breast cancer (MCF7) cell line.
AB - In a previous study, the methanolic extract as well as the chloroform fraction of the aerial parts of Caralluma quadrangula (Forssk.) N.E.Br. indigenous to Saudi Arabia showed significant in vitro cytotoxic activity against breast cancer (MCF7) cell line. In a biologically-guided fractionation approach, four acylated pregnane glycosides were isolated from the chloroform fraction of C. quadrangula. The structures of the isolated compounds were elucidated by the analysis of their MS and NMR data. The compounds were identified as 12,20-di-O-benzoylboucerin 3-O-?-D-digitoxopyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (1), 12,20-di-O-benzoylboucerin 3-O-?-D-cymaropyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (2), 12,20-di-O-benzoylboucerin 3-O-?-D-glucopyranosyl-(1?4)-?-D-digitoxopyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (3) and 12,20-di-O-benzoyl-3?,5?,12?,14?,20-pentahydroxy-(20R)-pregn-6-ene 3-O-?-D-glucopyranosyl-(1?4)-?-D-digitoxopyranosyl-(1?4)-?-D-canaropyranosyl-(1?4)-?-D-cymaropyranoside (4). The isolated compounds were tested for their cytotoxic activity against breast cancer (MCF7) cell line.
KW - Caralluma quadrangula
KW - Asclepiadaceae
KW - Pregnane glycosides
KW - Cytotoxicity on breast cancer
U2 - 10.1016/j.phytochem.2012.12.005
DO - 10.1016/j.phytochem.2012.12.005
M3 - Article
C2 - 23312459
SN - 0031-9422
VL - 88
SP - 54
EP - 60
JO - Phytochemistry
JF - Phytochemistry
ER -