Acute stress differentially affects spatial configuration learning in high and low cortisol-responding healthy adults

T. Meyer, T. Smeets, T. Giesbrecht, C.W.E.M. Quaedflieg, H. Merckelbach

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

BACKGROUND: Stress and stress hormones modulate memory formation in various ways that are relevant to our understanding of stress-related psychopathology, such as posttraumatic stress disorder (PTSD). Particular relevance is attributed to efficient memory formation sustained by the hippocampus and parahippocampus. This process is thought to reduce the occurrence of intrusions and flashbacks following trauma, but may be negatively affected by acute stress. Moreover, recent evidence suggests that the efficiency of visuo-spatial processing and learning based on the hippocampal area is related to PTSD symptoms. OBJECTIVE: The current study investigated the effect of acute stress on spatial configuration learning using a spatial contextual cueing task (SCCT) known to heavily rely on structures in the parahippocampus. METHOD: Acute stress was induced by subjecting participants (N = 34) to the Maastricht Acute Stress Test (MAST). Following a counterbalanced within-subject approach, the effects of stress and the ensuing hormonal (i.e., cortisol) activity on subsequent SCCT performance were compared to SCCT performance following a no-stress control condition. RESULTS: Acute stress did not impact SCCT learning overall, but opposing effects emerged for high versus low cortisol responders to the MAST. Learning scores following stress were reduced in low cortisol responders, while high cortisol-responding participants showed improved learning. CONCLUSIONS: The effects of stress on spatial configuration learning were moderated by the magnitude of endogenous cortisol secretion. These findings suggest a possible mechanism by which cortisol responses serve an adaptive function during stress and trauma, and this may prove to be a promising route for future research in this area.
Original languageEnglish
Article number19854
Number of pages9
JournalEuropean Journal of Psychotraumatology
Volume4
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • DISORDER
  • HUMANS
  • IMPLICIT
  • INFORMATION
  • MEMORY
  • MEN
  • Maastricht Acute Stress Test
  • PERFORMANCE
  • RELEVANCE
  • RESPONSES
  • WOMEN
  • contextual cueing paradigm
  • hippocampal area
  • posttraumatic stress disorder
  • spatial memory

Cite this

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abstract = "BACKGROUND: Stress and stress hormones modulate memory formation in various ways that are relevant to our understanding of stress-related psychopathology, such as posttraumatic stress disorder (PTSD). Particular relevance is attributed to efficient memory formation sustained by the hippocampus and parahippocampus. This process is thought to reduce the occurrence of intrusions and flashbacks following trauma, but may be negatively affected by acute stress. Moreover, recent evidence suggests that the efficiency of visuo-spatial processing and learning based on the hippocampal area is related to PTSD symptoms. OBJECTIVE: The current study investigated the effect of acute stress on spatial configuration learning using a spatial contextual cueing task (SCCT) known to heavily rely on structures in the parahippocampus. METHOD: Acute stress was induced by subjecting participants (N = 34) to the Maastricht Acute Stress Test (MAST). Following a counterbalanced within-subject approach, the effects of stress and the ensuing hormonal (i.e., cortisol) activity on subsequent SCCT performance were compared to SCCT performance following a no-stress control condition. RESULTS: Acute stress did not impact SCCT learning overall, but opposing effects emerged for high versus low cortisol responders to the MAST. Learning scores following stress were reduced in low cortisol responders, while high cortisol-responding participants showed improved learning. CONCLUSIONS: The effects of stress on spatial configuration learning were moderated by the magnitude of endogenous cortisol secretion. These findings suggest a possible mechanism by which cortisol responses serve an adaptive function during stress and trauma, and this may prove to be a promising route for future research in this area.",
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Acute stress differentially affects spatial configuration learning in high and low cortisol-responding healthy adults. / Meyer, T.; Smeets, T.; Giesbrecht, T.; Quaedflieg, C.W.E.M.; Merckelbach, H.

In: European Journal of Psychotraumatology, Vol. 4, 19854, 01.01.2013.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Acute stress differentially affects spatial configuration learning in high and low cortisol-responding healthy adults

AU - Meyer, T.

AU - Smeets, T.

AU - Giesbrecht, T.

AU - Quaedflieg, C.W.E.M.

AU - Merckelbach, H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Stress and stress hormones modulate memory formation in various ways that are relevant to our understanding of stress-related psychopathology, such as posttraumatic stress disorder (PTSD). Particular relevance is attributed to efficient memory formation sustained by the hippocampus and parahippocampus. This process is thought to reduce the occurrence of intrusions and flashbacks following trauma, but may be negatively affected by acute stress. Moreover, recent evidence suggests that the efficiency of visuo-spatial processing and learning based on the hippocampal area is related to PTSD symptoms. OBJECTIVE: The current study investigated the effect of acute stress on spatial configuration learning using a spatial contextual cueing task (SCCT) known to heavily rely on structures in the parahippocampus. METHOD: Acute stress was induced by subjecting participants (N = 34) to the Maastricht Acute Stress Test (MAST). Following a counterbalanced within-subject approach, the effects of stress and the ensuing hormonal (i.e., cortisol) activity on subsequent SCCT performance were compared to SCCT performance following a no-stress control condition. RESULTS: Acute stress did not impact SCCT learning overall, but opposing effects emerged for high versus low cortisol responders to the MAST. Learning scores following stress were reduced in low cortisol responders, while high cortisol-responding participants showed improved learning. CONCLUSIONS: The effects of stress on spatial configuration learning were moderated by the magnitude of endogenous cortisol secretion. These findings suggest a possible mechanism by which cortisol responses serve an adaptive function during stress and trauma, and this may prove to be a promising route for future research in this area.

AB - BACKGROUND: Stress and stress hormones modulate memory formation in various ways that are relevant to our understanding of stress-related psychopathology, such as posttraumatic stress disorder (PTSD). Particular relevance is attributed to efficient memory formation sustained by the hippocampus and parahippocampus. This process is thought to reduce the occurrence of intrusions and flashbacks following trauma, but may be negatively affected by acute stress. Moreover, recent evidence suggests that the efficiency of visuo-spatial processing and learning based on the hippocampal area is related to PTSD symptoms. OBJECTIVE: The current study investigated the effect of acute stress on spatial configuration learning using a spatial contextual cueing task (SCCT) known to heavily rely on structures in the parahippocampus. METHOD: Acute stress was induced by subjecting participants (N = 34) to the Maastricht Acute Stress Test (MAST). Following a counterbalanced within-subject approach, the effects of stress and the ensuing hormonal (i.e., cortisol) activity on subsequent SCCT performance were compared to SCCT performance following a no-stress control condition. RESULTS: Acute stress did not impact SCCT learning overall, but opposing effects emerged for high versus low cortisol responders to the MAST. Learning scores following stress were reduced in low cortisol responders, while high cortisol-responding participants showed improved learning. CONCLUSIONS: The effects of stress on spatial configuration learning were moderated by the magnitude of endogenous cortisol secretion. These findings suggest a possible mechanism by which cortisol responses serve an adaptive function during stress and trauma, and this may prove to be a promising route for future research in this area.

KW - DISORDER

KW - HUMANS

KW - IMPLICIT

KW - INFORMATION

KW - MEMORY

KW - MEN

KW - Maastricht Acute Stress Test

KW - PERFORMANCE

KW - RELEVANCE

KW - RESPONSES

KW - WOMEN

KW - contextual cueing paradigm

KW - hippocampal area

KW - posttraumatic stress disorder

KW - spatial memory

U2 - 10.3402/ejpt.v4i0.19854

DO - 10.3402/ejpt.v4i0.19854

M3 - Article

VL - 4

JO - European Journal of Psychotraumatology

JF - European Journal of Psychotraumatology

SN - 2000-8198

M1 - 19854

ER -