Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

Kathryn A. Martinello; Christopher Meehan; Adnan Avdic-Belltheus; Ingran Lingam; Sara Ragab; Mariya Hristova; Cally J. Tann; Donald Peebles; Henrik Hagberg; Tim G. A. M. Wolfs; Nigel Klein; Ilias Tachtsidis; Xavier Golay; Boris W. Kramer; Bobbi Fleiss; Pierre Gressens; Nicola J. Robertson

doi:10.1038/s41598-019-46488-y

Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Sara Ragab, Mariya Hristova, Cally J. Tann, Donald Peebles, Henrik Hagberg, Tim G. A. M. Wolfs, Nigel Klein, Ilias Tachtsidis, Xavier Golay, Boris W. Kramer, Bobbi Fleiss, Pierre Gressens, Nicola J. Robertson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	10184
Number of pages	17
Journal	Scientific Reports
Volume	9
DOIs	https://doi.org/10.1038/s41598-019-46488-y
Publication status	Published - 15 Jul 2019

Keywords

PHOSPHORUS MAGNETIC-RESONANCE
CEREBRAL-PALSY
THERAPEUTIC HYPOTHERMIA
ISCHEMIC ENCEPHALOPATHY
MICROGLIA ACTIVATION
CLINICAL-TRIAL
INFANTS
LIPOPOLYSACCHARIDE
TERM
INFECTION

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10.1038/s41598-019-46488-yLicence: CC BY

Cite this

Martinello, K. A., Meehan, C., Avdic-Belltheus, A., Lingam, I., Ragab, S., Hristova, M., Tann, C. J., Peebles, D., Hagberg, H., Wolfs, T. G. A. M., Klein, N., Tachtsidis, I., Golay, X., Kramer, B. W., Fleiss, B., Gressens, P., & Robertson, N. J. (2019). Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy. Scientific Reports, 9, [10184]. https://doi.org/10.1038/s41598-019-46488-y

Martinello, Kathryn A. ; Meehan, Christopher ; Avdic-Belltheus, Adnan ; Lingam, Ingran ; Ragab, Sara ; Hristova, Mariya ; Tann, Cally J. ; Peebles, Donald ; Hagberg, Henrik ; Wolfs, Tim G. A. M. ; Klein, Nigel ; Tachtsidis, Ilias ; Golay, Xavier ; Kramer, Boris W. ; Fleiss, Bobbi ; Gressens, Pierre ; Robertson, Nicola J. / Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy. In: Scientific Reports. 2019 ; Vol. 9.

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title = "Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy",

keywords = "PHOSPHORUS MAGNETIC-RESONANCE, CEREBRAL-PALSY, THERAPEUTIC HYPOTHERMIA, ISCHEMIC ENCEPHALOPATHY, MICROGLIA ACTIVATION, CLINICAL-TRIAL, INFANTS, LIPOPOLYSACCHARIDE, TERM, INFECTION",

author = "Martinello, {Kathryn A.} and Christopher Meehan and Adnan Avdic-Belltheus and Ingran Lingam and Sara Ragab and Mariya Hristova and Tann, {Cally J.} and Donald Peebles and Henrik Hagberg and Wolfs, {Tim G. A. M.} and Nigel Klein and Ilias Tachtsidis and Xavier Golay and Kramer, {Boris W.} and Bobbi Fleiss and Pierre Gressens and Robertson, {Nicola J.}",

year = "2019",

month = jul,

day = "15",

doi = "10.1038/s41598-019-46488-y",

language = "English",

volume = "9",

journal = "Scientific Reports",

issn = "2045-2322",

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Martinello, KA, Meehan, C, Avdic-Belltheus, A, Lingam, I, Ragab, S, Hristova, M, Tann, CJ, Peebles, D, Hagberg, H, Wolfs, TGAM, Klein, N, Tachtsidis, I, Golay, X, Kramer, BW, Fleiss, B, Gressens, P & Robertson, NJ 2019, 'Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy', Scientific Reports, vol. 9, 10184. https://doi.org/10.1038/s41598-019-46488-y

Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy. / Martinello, Kathryn A.; Meehan, Christopher; Avdic-Belltheus, Adnan; Lingam, Ingran; Ragab, Sara; Hristova, Mariya; Tann, Cally J.; Peebles, Donald; Hagberg, Henrik; Wolfs, Tim G. A. M.; Klein, Nigel; Tachtsidis, Ilias; Golay, Xavier; Kramer, Boris W.; Fleiss, Bobbi; Gressens, Pierre; Robertson, Nicola J.

In: Scientific Reports, Vol. 9, 10184, 15.07.2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

AU - Martinello, Kathryn A.

AU - Meehan, Christopher

AU - Avdic-Belltheus, Adnan

AU - Lingam, Ingran

AU - Ragab, Sara

AU - Hristova, Mariya

AU - Tann, Cally J.

AU - Peebles, Donald

AU - Hagberg, Henrik

AU - Wolfs, Tim G. A. M.

AU - Klein, Nigel

AU - Tachtsidis, Ilias

AU - Golay, Xavier

AU - Kramer, Boris W.

AU - Fleiss, Bobbi

AU - Gressens, Pierre

AU - Robertson, Nicola J.

PY - 2019/7/15

Y1 - 2019/7/15

KW - PHOSPHORUS MAGNETIC-RESONANCE

KW - CEREBRAL-PALSY

KW - THERAPEUTIC HYPOTHERMIA

KW - ISCHEMIC ENCEPHALOPATHY

KW - MICROGLIA ACTIVATION

KW - CLINICAL-TRIAL

KW - INFANTS

KW - LIPOPOLYSACCHARIDE

KW - TERM

KW - INFECTION

U2 - 10.1038/s41598-019-46488-y

DO - 10.1038/s41598-019-46488-y

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10184

ER -