Acute Kidney Injury After Efavirenz/Tenofovir Disoproxil Fumarate/Emtricitabine (Atripla) Overdose

Thomas Havenith; David Burger; Maarten J Visschers; Jolanda Schippers; Astrid Oude Lashof

doi:10.1097/FTD.0000000000000386

Acute Kidney Injury After Efavirenz/Tenofovir Disoproxil Fumarate/Emtricitabine (Atripla) Overdose

Thomas Havenith^*, David Burger, Maarten J Visschers, Jolanda Schippers, Astrid Oude Lashof

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.

Original language	English
Pages (from-to)	91-92
Number of pages	2
Journal	Therapeutic Drug Monitoring
Volume	39
Issue number	2
DOIs	https://doi.org/10.1097/FTD.0000000000000386
Publication status	Published - Apr 2017

Keywords

Acute Kidney Injury
Anti-HIV Agents
Benzoxazines
Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Emtricitabine
HIV Infections
HIV-1
Humans
Male
Middle Aged
Tenofovir
Case Reports
Journal Article

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10.1097/FTD.0000000000000386

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title = "Acute Kidney Injury After Efavirenz/Tenofovir Disoproxil Fumarate/Emtricitabine (Atripla) Overdose",

abstract = "We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.",

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author = "Thomas Havenith and David Burger and Visschers, \{Maarten J\} and Jolanda Schippers and \{Oude Lashof\}, Astrid",

year = "2017",

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doi = "10.1097/FTD.0000000000000386",

language = "English",

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AU - Burger, David

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AU - Schippers, Jolanda

AU - Oude Lashof, Astrid

PY - 2017/4

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N2 - We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.

AB - We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.

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KW - Anti-HIV Agents

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KW - Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination

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KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Middle Aged

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KW - Case Reports

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JF - Therapeutic Drug Monitoring

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ER -

Acute Kidney Injury After Efavirenz/Tenofovir Disoproxil Fumarate/Emtricitabine (Atripla) Overdose

Abstract

Keywords

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