Acute Kidney Injury After Efavirenz/Tenofovir Disoproxil Fumarate/Emtricitabine (Atripla) Overdose

Thomas Havenith, David Burger, Maarten J Visschers, Jolanda Schippers, Astrid Oude Lashof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.

Original languageEnglish
Pages (from-to)91-92
Number of pages2
JournalTherapeutic Drug Monitoring
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Acute Kidney Injury
  • Anti-HIV Agents
  • Benzoxazines
  • Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
  • Emtricitabine
  • HIV Infections
  • HIV-1
  • Humans
  • Male
  • Middle Aged
  • Tenofovir
  • Case Reports
  • Journal Article

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