Acute effects of nebulized salbutamol on resting energy expenditure in patients with chronic obstructive pulmonary disease and in healthy subjects.

E.C. Creutzberg*, A.M.W.J. Schols, F.C.M. Bothmer-Quaedvlieg, G.J. Wesseling, E.F.M. Wouters

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Department of Pulmonology, University Hospital Maastricht, The Netherlands.

This study investigated the contribution of a single dose of salbutamol by nebulizer to the increased resting energy expenditure (REE) frequently found in patients with chronic obstructive pulmonary disease (COPD) (n = 22), in comparison with a younger (n = 15) and an older healthy (n = 10) control group. The rise in REE after nebulization of 5 mg salbutamol was significantly higher in younger (11.4%) compared to older healthy subjects (5.7%; p < 0.05) and patients with COPD (4.2%; p < 0.001), which also accounted for the increase in heart rate and the drop in the respiratory quotient. No differences in metabolic effects were found between older control subjects and patients with COPD. In conclusion, despite significant improvements in FEV1 and airway resistance, a significant rise in REE was observed in patients with COPD after nebulization of salbutamol. The metabolic effects of salbutamol were however not sufficient to explain totally the elevated REE seen in these patients.
Original languageEnglish
Pages (from-to)375-380
Number of pages6
Issue number5
Publication statusPublished - 1 Jan 1998

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