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Activation of the NLRP3 inflammasome in microglia: the role of ceramide
Hannah Scheiblich
, Anna Schlütter
, Douglas T. Golenbock
, Eicke Latz
,
Pilar Martinez-Martinez
, Michael T. Heneka
*
*
Corresponding author for this work
MHeNs - Neuroscience
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Keyphrases
NOD-like Receptor Protein 3 (NLRP3)
100%
Microglia
100%
Ceramide
100%
Pyrin Domain Containing 3 Inflammasome
100%
Interleukin-1β
87%
Inflammasome Activation
37%
Inflammasome Assembly
37%
Caspase-1
25%
Serine Palmitoyltransferase
25%
Inflammatory Cytokines
12%
Receptor Agonist
12%
Bioactive
12%
Inflammation
12%
Neurodegenerative Diseases
12%
Immune Response
12%
Palmitate
12%
Major Components
12%
Microglial Cells
12%
Sphingosine-1-phosphate Receptor (S1PR)
12%
Fingolimod
12%
FTY720
12%
Activated Microglia
12%
Inflammasome
12%
Ceramide Signaling
12%
HPA-12
12%
Positive Modulator
12%
Ceramide Synthesis
12%
Apoptosis-associated Speck-like Protein Containing A CARD
12%
Cleaved Caspase
12%
Sodium Palmitate
12%
D-cycloserine
12%
Ceramide NP
12%
Neuroscience
Microglia
100%
Ceramide
100%
Inflammasome
100%
Pyrin Domain
100%
NOD-like Receptor
100%
Interleukin 1beta
70%
Palmitic Acid
20%
Serine Palmitoyltransferase
20%
Caspase 1
20%
Fingolimod
20%
Neurodegenerative Disorder
10%
Proinflammatory Cytokine
10%
Receptor Agonists
10%
Transferase Inhibitor
10%
Sphingosine-1-Phosphate Receptor
10%
Cycloserine
10%
Programmed Cell Death
10%
Immunology and Microbiology
Pyrin Domain
100%
Microglia
100%
NOD-like Receptor
100%
Inflammasome
100%
Interleukin-1
70%
Secretion (Process)
30%
Wild Type
20%
Caspase 1
20%
Fingolimod
20%
Serine
20%
Cytokine
10%
Agonist
10%
Proinflammatory Cytokine
10%
Immune Response
10%
Programmed Cell Death
10%
INIS
receptors
100%
secretion
50%
levels
33%
inflammation
33%
cytokines
33%
proteins
33%
serine
33%
transferases
33%
phosphates
16%
applications
16%
modulation
16%
apoptosis
16%
inhibition
16%
sodium
16%
enzymes
16%
synthesis
16%
injuries
16%
transport
16%
nervous system diseases
16%
knock-out reactions
16%