Acetylcarnitine: The role in metabolic exibility and insulin sensitivity

Research output: ThesisDoctoral ThesisInternal

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Abstract

The incidence of Type 2 diabetes is on the rise. This disease is characterised by the body not responding effectively to the hormone insulin (i.e. insulin resistance) and a reduced ability to switch between fat burning and glucose burning. As a result, blood glucose levels rise cannot be maintained properly and will therefore rise. By means of magnetic resonance spectroscopy (MRS), this dissertation demonstrated the importance of acetylcarnitine formation, which plays a key role in muscle energy metabolism, for maintaining glucose homeostasis. The main conclusion is that carnitine intake increases acetylcarnitine formation and improves the ability to switch between glucose burning and fat burning in muscles.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schrauwen, Patrick, Supervisor
  • Wildberger, Joachim, Supervisor
  • Schrauwen - Hinderling, Vera, Advisor
Award date14 Jun 2018
Place of PublicationEnschede
Publisher
Print ISBNs9789462339736
DOIs
Publication statusPublished - 2018

Keywords

  • Type 2 diabetes
  • insulin
  • fat burning
  • glucose burning
  • MRS
  • acetylcarnitine

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