Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children.

B.G. Koot, O.H. van der Baan Slootweg, A.E. Bohte, A.J. Nederveen, J.R. van Werven, C.I. Tamminga-Smeulders, M.P. Merkus, F.G. Schaap, P.L. Jansen, J. Stoker, M.A. Benninga

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Accurate prediction scores for liver steatosis are demanded clinicians to noninvasively screen for nonalcoholic fatty liver disease Several prediction scores have been developed, however external lacking. OBJECTIVE: The aim was to determine the diagnostic accuracy of existing prediction scores in severely obese children, to develop a new prediction score using novel biomarkers and to compare these results to performance of ultrasonography. DESIGN AND RESULTS: Liver steatosis was using proton magnetic resonance spectroscopy in 119 severely obese age 14.3 +/- 2.1 years, BMI z-score 3.35 +/- 0.35). Prevalence of 47%. The four existing predictions scores ("NAFLD liver fat score," index," "hepatic steatosis index," and the pediatric prediction score) moderate diagnostic accuracy in this cohort (positive predictive value 61, 61, 69% and negative predictive value (NPV) 77, 69, 68, 75%, new prediction score was built using anthropometry, routine biochemistry novel biomarkers (leptin, adiponectin, TNF-alpha, IL-6, CK-18, FGF-21, adiponutrin polymorphisms). The final model included ALT, HOMA, sex, and This equation (PPV 79% and NPV 80%) did not perform substantially better four other equations and did not outperform ultrasonography for (NPV 82%). CONCLUSION: The conclusion is in severely obese children and adolescents existing prediction scores and the tested novel biomarkers insufficient diagnostic accuracy for diagnosing or excluding NAFLD.
Original languageEnglish
Pages (from-to)583-590
Number of pages8
JournalObesity
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • GROWTH-FACTOR 21
  • HEPATIC STEATOSIS
  • DIAGNOSTIC-ACCURACY
  • INSULIN-RESISTANCE
  • NAFLD
  • STEATOHEPATITIS
  • SEVERITY
  • FIBROSIS
  • US
  • ADOLESCENTS

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