Accuracy of OCT Curvature and Aberrations of Bowman's Layer: A Prospective Comparison With Physical Removal of Epithelium

Pooja Khamar, Rohit Shetty, Prerna Ahuja, Rachana Chandapura, Raghav Narasimhan, Rudy M M A Nuijts, Abhijit Sinha Roy*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

PURPOSE: To compare optical coherence tomography (OCT) and Scheimpflug curvature and aberrations of the Bowman's layer before and after removal of the epithelium.

METHODS: Bowman's layer was mapped with OCT (Optovue Inc., Irvine, CA) before and after removal of the epithelium in normal eyes undergoing photorefractive keratectomy (n = 14) and keratoconic eyes undergoing corneal cross-linking (n = 25). The anterior corneal surface before removal and the underlying Bowman's layer after removal of the epithelium were also mapped with Pentacam (Oculus Optikgeräte, Wetzlar, Germany), and the surface aberrations with ray tracing were computed.

RESULTS: The agreement of OCT curvatures before and after removal of the epithelium was excellent (intraclass correlation coefficient [ICC] = 0.9). A similar trend was seen between OCT and Pentacam after removal of the epithelium. The agreement of surface wavefront aberrations of the Bowman's layer before and after removal of the epithelium was excellent (ICC = 0.9) between the devices for keratoconic eyes. However, this agreement was relatively inferior in normal eyes (ICC < 0.5).

CONCLUSIONS: The virtual OCT curvature and aberrations of the Bowman's layer agreed well with its actual magnitudes on removal of the epithelium in the keratoconic eyes. In normal eyes, the agreement was inferior for aberrations but not for curvature. [J Refract Surg. 2020;36(3):193-198.].

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalJournal of Refractive Surgery
Volume36
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • Adult
  • Bowman Membrane/diagnostic imaging
  • Corneal Topography
  • Corneal Wavefront Aberration/physiopathology
  • Cross-Sectional Studies
  • Epithelium, Corneal/surgery
  • Female
  • Humans
  • Keratoconus/physiopathology
  • Lasers, Excimer/therapeutic use
  • Male
  • Photorefractive Keratectomy/methods
  • Prospective Studies
  • Reproducibility of Results
  • Tomography, Optical Coherence
  • Young Adult
  • CORNEAL EPITHELIUM
  • TOPOGRAPHY
  • REPAIR
  • SURFACE

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