Accuracy of estimated total liver volume formulas before liver resection

Pim B. Olthof; Ronald van Dam; Elio Jovine; Ricardo Robles Campos; Eduardo de Santibanes; Karl Oldhafer; Massimo Malago; Eddie K. Abdalla; Erik Schadde

doi:10.1016/j.surg.2019.05.003

Accuracy of estimated total liver volume formulas before liver resection

Pim B. Olthof^*, Ronald van Dam, Elio Jovine, Ricardo Robles Campos, Eduardo de Santibanes, Karl Oldhafer, Massimo Malago, Eddie K. Abdalla, Erik Schadde

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Web of Science)

Abstract

Background: Future remnant liver volume is used to predict the risk for liver failure in patients who will undergo major liver resection. Formulas to estimate total liver volume based on biometric data are widely used to calculate future remnant liver volume; however, it remains unclear which formula is most accurate. This study evaluated published estimate total liver volume formulas to determine which formula best predicts the actual future remnant liver volume based on measurements in a large number of patients who underwent associating liver partition and portal vein ligation for staged hepatectomy surgery.

Methods: All patients with complete liver volume data in the associating liver partition and portal vein ligation for staged hepatectomy registry were included in this study. Estimate total liver volume and estimated future remnant liver volume were calculated for 16 published formulas. The median over- or underestimation compared with actual measured volumes were determined for estimate total liver volume and future remnant liver volume. The proportion of patients with an under- or overestimated future remnant liver volume for each formula were compared with each other using a 25% cut-off for each formula.

Results: Among 529 studied patients, the formulas ranged from a 19% underestimation to a 63% overestimation of estimate total liver volume. Estimation of future remnant liver volume lead to a 10% underestimation to a 5% overestimation among the formulas. Of all studied formulas, the Vautheyl formula was the most accurate, generating underestimation of future remnant liver volume in 20% and overestimation of future remnant liver volume in 6% of patients.

Conclusion: Validation of 16 published total liver volume formulas in a multicenter international cohort of 529 patients that underwent staged hepatectomy revealed that the Vauthey formula (estimate total liver volume =18.51 x body weight + 191.8) provides the most accurate prediction of the actual future remnant liver volume. (C) 2019 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	247-253
Number of pages	7
Journal	Surgery
Volume	166
Issue number	3
DOIs	https://doi.org/10.1016/j.surg.2019.05.003
Publication status	Published - Sept 2019

Keywords

TC-99M-MEBROFENIN HEPATOBILIARY SCINTIGRAPHY
REMNANT LIVER
BODY-WEIGHT
SURFACE-AREA
STANDARD
TRANSPLANTATION
FAILURE
CT
SOFTWARE
SIZE

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10.1016/j.surg.2019.05.003

Cite this

@article{14c6ed6691674385acb824ed463ef6a7,

title = "Accuracy of estimated total liver volume formulas before liver resection",

abstract = "Background: Future remnant liver volume is used to predict the risk for liver failure in patients who will undergo major liver resection. Formulas to estimate total liver volume based on biometric data are widely used to calculate future remnant liver volume; however, it remains unclear which formula is most accurate. This study evaluated published estimate total liver volume formulas to determine which formula best predicts the actual future remnant liver volume based on measurements in a large number of patients who underwent associating liver partition and portal vein ligation for staged hepatectomy surgery.Methods: All patients with complete liver volume data in the associating liver partition and portal vein ligation for staged hepatectomy registry were included in this study. Estimate total liver volume and estimated future remnant liver volume were calculated for 16 published formulas. The median over- or underestimation compared with actual measured volumes were determined for estimate total liver volume and future remnant liver volume. The proportion of patients with an under- or overestimated future remnant liver volume for each formula were compared with each other using a 25% cut-off for each formula.Results: Among 529 studied patients, the formulas ranged from a 19% underestimation to a 63% overestimation of estimate total liver volume. Estimation of future remnant liver volume lead to a 10% underestimation to a 5% overestimation among the formulas. Of all studied formulas, the Vautheyl formula was the most accurate, generating underestimation of future remnant liver volume in 20% and overestimation of future remnant liver volume in 6% of patients.Conclusion: Validation of 16 published total liver volume formulas in a multicenter international cohort of 529 patients that underwent staged hepatectomy revealed that the Vauthey formula (estimate total liver volume =18.51 x body weight + 191.8) provides the most accurate prediction of the actual future remnant liver volume. (C) 2019 Elsevier Inc. All rights reserved.",

keywords = "TC-99M-MEBROFENIN HEPATOBILIARY SCINTIGRAPHY, REMNANT LIVER, BODY-WEIGHT, SURFACE-AREA, STANDARD, TRANSPLANTATION, FAILURE, CT, SOFTWARE, SIZE",

author = "Olthof, {Pim B.} and {van Dam}, Ronald and Elio Jovine and Campos, {Ricardo Robles} and {de Santibanes}, Eduardo and Karl Oldhafer and Massimo Malago and Abdalla, {Eddie K.} and Erik Schadde",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

doi = "10.1016/j.surg.2019.05.003",

language = "English",

volume = "166",

pages = "247--253",

journal = "Surgery",

issn = "0039-6060",

publisher = "MOSBY-ELSEVIER",

number = "3",

}

TY - JOUR

T1 - Accuracy of estimated total liver volume formulas before liver resection

AU - Olthof, Pim B.

AU - van Dam, Ronald

AU - Jovine, Elio

AU - Campos, Ricardo Robles

AU - de Santibanes, Eduardo

AU - Oldhafer, Karl

AU - Malago, Massimo

AU - Abdalla, Eddie K.

AU - Schadde, Erik

PY - 2019/9

Y1 - 2019/9

N2 - Background: Future remnant liver volume is used to predict the risk for liver failure in patients who will undergo major liver resection. Formulas to estimate total liver volume based on biometric data are widely used to calculate future remnant liver volume; however, it remains unclear which formula is most accurate. This study evaluated published estimate total liver volume formulas to determine which formula best predicts the actual future remnant liver volume based on measurements in a large number of patients who underwent associating liver partition and portal vein ligation for staged hepatectomy surgery.Methods: All patients with complete liver volume data in the associating liver partition and portal vein ligation for staged hepatectomy registry were included in this study. Estimate total liver volume and estimated future remnant liver volume were calculated for 16 published formulas. The median over- or underestimation compared with actual measured volumes were determined for estimate total liver volume and future remnant liver volume. The proportion of patients with an under- or overestimated future remnant liver volume for each formula were compared with each other using a 25% cut-off for each formula.Results: Among 529 studied patients, the formulas ranged from a 19% underestimation to a 63% overestimation of estimate total liver volume. Estimation of future remnant liver volume lead to a 10% underestimation to a 5% overestimation among the formulas. Of all studied formulas, the Vautheyl formula was the most accurate, generating underestimation of future remnant liver volume in 20% and overestimation of future remnant liver volume in 6% of patients.Conclusion: Validation of 16 published total liver volume formulas in a multicenter international cohort of 529 patients that underwent staged hepatectomy revealed that the Vauthey formula (estimate total liver volume =18.51 x body weight + 191.8) provides the most accurate prediction of the actual future remnant liver volume. (C) 2019 Elsevier Inc. All rights reserved.

AB - Background: Future remnant liver volume is used to predict the risk for liver failure in patients who will undergo major liver resection. Formulas to estimate total liver volume based on biometric data are widely used to calculate future remnant liver volume; however, it remains unclear which formula is most accurate. This study evaluated published estimate total liver volume formulas to determine which formula best predicts the actual future remnant liver volume based on measurements in a large number of patients who underwent associating liver partition and portal vein ligation for staged hepatectomy surgery.Methods: All patients with complete liver volume data in the associating liver partition and portal vein ligation for staged hepatectomy registry were included in this study. Estimate total liver volume and estimated future remnant liver volume were calculated for 16 published formulas. The median over- or underestimation compared with actual measured volumes were determined for estimate total liver volume and future remnant liver volume. The proportion of patients with an under- or overestimated future remnant liver volume for each formula were compared with each other using a 25% cut-off for each formula.Results: Among 529 studied patients, the formulas ranged from a 19% underestimation to a 63% overestimation of estimate total liver volume. Estimation of future remnant liver volume lead to a 10% underestimation to a 5% overestimation among the formulas. Of all studied formulas, the Vautheyl formula was the most accurate, generating underestimation of future remnant liver volume in 20% and overestimation of future remnant liver volume in 6% of patients.Conclusion: Validation of 16 published total liver volume formulas in a multicenter international cohort of 529 patients that underwent staged hepatectomy revealed that the Vauthey formula (estimate total liver volume =18.51 x body weight + 191.8) provides the most accurate prediction of the actual future remnant liver volume. (C) 2019 Elsevier Inc. All rights reserved.

KW - TC-99M-MEBROFENIN HEPATOBILIARY SCINTIGRAPHY

KW - REMNANT LIVER

KW - BODY-WEIGHT

KW - SURFACE-AREA

KW - STANDARD

KW - TRANSPLANTATION

KW - FAILURE

KW - CT

KW - SOFTWARE

KW - SIZE

U2 - 10.1016/j.surg.2019.05.003

DO - 10.1016/j.surg.2019.05.003

M3 - Article

SN - 0039-6060

VL - 166

SP - 247

EP - 253

JO - Surgery

JF - Surgery

IS - 3

ER -