Accelerometer-measured dose-response for physical activity, sedentary time, and mortality in US adults

Charles E. Matthews*, Sarah Kozey Keadle, Richard P. Troiano, Lisa Kahle, Annemarie Koster, Robert Brychta, Dane Van Domelen, Paolo Caserotti, Kong Y. Chen, Tamara B. Harris, David Berrigan

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background: Moderate-to-vigorous intensity physical activity is recommended to maintain and improve health, but the mortality benefits of light activity and risk for sedentary time remain uncertain. Objectives: Using accelerometer-based measures, we 1) described the mortality dose-response for sedentary time and light- and moderate-to-vigorous intensity activity using restricted cubic splines, and 2) estimated the mortality benefits associated with replacing sedentary time with physical activity, accounting for total activity. Design: US adults (n = 4840) from NHANES (2003-2006) wore an accelerometer for
Original languageEnglish
Pages (from-to)1424-1432
JournalAmerican Journal of Clinical Nutrition
Issue number5
Publication statusPublished - Nov 2016


  • sedentary behavior
  • physical activity
  • mortality
  • accelerometer
  • light-intensity activity
  • moderate-to-vigorous intensity activity

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