ACCELERATED BONE FORMATION BY BIPHASIC CALCIUM PHOSPHATE WITH A NOVEL SUB-MICRON SURFACE TOPOGRAPHY

R. Duan, L. A. van Dijk, D. Barbieri, F. de Groot, H. Yuan, J. D. de Bruijn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Web of Science)

Abstract

Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic calcium phosphate (BCP) bone grafts were synthesised with either sub-micron- (BCP surface feature morphology > substrate chemistry. BCP materials with needleshaped sub-micron surface topography gave rise to accelerated bone formation and slower rate of resorption than a comparable TCP. These characteristics may be translated to improve bone healing in orthotopic defects.

Original languageEnglish
Pages (from-to)60-73
Number of pages14
JournalEuropean Cells & Materials
Volume37
DOIs
Publication statusPublished - 2019

Keywords

  • Osteoinduction
  • calcium phosphate
  • bone graft
  • surface topography
  • sub-micron-scale
  • needle crystal
  • MESENCHYMAL STEM-CELLS
  • OSTEOGENIC DIFFERENTIATION
  • MORPHOGENETIC PROTEIN
  • GRAFT SUBSTITUTE
  • HYDROXYAPATITE
  • OSTEOINDUCTION
  • CERAMICS
  • SHAPE
  • OSTEOCLASTOGENESIS
  • BIOMATERIALS

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