ACCELERATED BONE FORMATION BY BIPHASIC CALCIUM PHOSPHATE WITH A NOVEL SUB-MICRON SURFACE TOPOGRAPHY

R. Duan; L. A. van Dijk; D. Barbieri; F. de Groot; H. Yuan; J. D. de Bruijn

doi:10.22203/eCM.v037a05

ACCELERATED BONE FORMATION BY BIPHASIC CALCIUM PHOSPHATE WITH A NOVEL SUB-MICRON SURFACE TOPOGRAPHY

R. Duan, L. A. van Dijk, D. Barbieri, F. de Groot, H. Yuan, J. D. de Bruijn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic calcium phosphate (BCP) bone grafts were synthesised with either sub-micron- (BCP surface feature morphology > substrate chemistry. BCP materials with needleshaped sub-micron surface topography gave rise to accelerated bone formation and slower rate of resorption than a comparable TCP. These characteristics may be translated to improve bone healing in orthotopic defects.

Original language	English
Pages (from-to)	60-73
Number of pages	14
Journal	European Cells & Materials
Volume	37
DOIs	https://doi.org/10.22203/eCM.v037a05
Publication status	Published - 2019

Keywords

Osteoinduction
calcium phosphate
bone graft
surface topography
sub-micron-scale
needle crystal
MESENCHYMAL STEM-CELLS
OSTEOGENIC DIFFERENTIATION
MORPHOGENETIC PROTEIN
GRAFT SUBSTITUTE
HYDROXYAPATITE
OSTEOINDUCTION
CERAMICS
SHAPE
OSTEOCLASTOGENESIS
BIOMATERIALS

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Cite this

@article{85927686b5734d6a8c20c3da044f61d9,

title = "ACCELERATED BONE FORMATION BY BIPHASIC CALCIUM PHOSPHATE WITH A NOVEL SUB-MICRON SURFACE TOPOGRAPHY",

abstract = "Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic calcium phosphate (BCP) bone grafts were synthesised with either sub-micron- (BCP surface feature morphology > substrate chemistry. BCP materials with needleshaped sub-micron surface topography gave rise to accelerated bone formation and slower rate of resorption than a comparable TCP. These characteristics may be translated to improve bone healing in orthotopic defects.",

keywords = "Osteoinduction, calcium phosphate, bone graft, surface topography, sub-micron-scale, needle crystal, MESENCHYMAL STEM-CELLS, OSTEOGENIC DIFFERENTIATION, MORPHOGENETIC PROTEIN, GRAFT SUBSTITUTE, HYDROXYAPATITE, OSTEOINDUCTION, CERAMICS, SHAPE, OSTEOCLASTOGENESIS, BIOMATERIALS",

author = "R. Duan and {van Dijk}, {L. A.} and D. Barbieri and {de Groot}, F. and H. Yuan and {de Bruijn}, {J. D.}",

year = "2019",

doi = "10.22203/eCM.v037a05",

language = "English",

volume = "37",

pages = "60--73",

journal = "European Cells & Materials",

issn = "1473-2262",

publisher = "AO Research Institute Davos (ARI)",

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T1 - ACCELERATED BONE FORMATION BY BIPHASIC CALCIUM PHOSPHATE WITH A NOVEL SUB-MICRON SURFACE TOPOGRAPHY

AU - Duan, R.

AU - van Dijk, L. A.

AU - Barbieri, D.

AU - de Groot, F.

AU - Yuan, H.

AU - de Bruijn, J. D.

PY - 2019

Y1 - 2019

N2 - Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic calcium phosphate (BCP) bone grafts were synthesised with either sub-micron- (BCP surface feature morphology > substrate chemistry. BCP materials with needleshaped sub-micron surface topography gave rise to accelerated bone formation and slower rate of resorption than a comparable TCP. These characteristics may be translated to improve bone healing in orthotopic defects.

AB - Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic calcium phosphate (BCP) bone grafts were synthesised with either sub-micron- (BCP surface feature morphology > substrate chemistry. BCP materials with needleshaped sub-micron surface topography gave rise to accelerated bone formation and slower rate of resorption than a comparable TCP. These characteristics may be translated to improve bone healing in orthotopic defects.

KW - Osteoinduction

KW - calcium phosphate

KW - bone graft

KW - surface topography

KW - sub-micron-scale

KW - needle crystal

KW - MESENCHYMAL STEM-CELLS

KW - OSTEOGENIC DIFFERENTIATION

KW - MORPHOGENETIC PROTEIN

KW - GRAFT SUBSTITUTE

KW - HYDROXYAPATITE

KW - OSTEOINDUCTION

KW - CERAMICS

KW - SHAPE

KW - OSTEOCLASTOGENESIS

KW - BIOMATERIALS

U2 - 10.22203/eCM.v037a05

DO - 10.22203/eCM.v037a05

M3 - Article

SN - 1473-2262

VL - 37

SP - 60

EP - 73

JO - European Cells & Materials

JF - European Cells & Materials

ER -