Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates

K. G. G. van Kol*, T. F. M. Vergeldt, R. L. M. Bekkers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Web of Science)

Abstract

Introduction: There is currently no standard of care for women with cervical cancer stage IB2 (FIGO 2018, >= 2 cm and

Objective: To compare rates of fertility, pregnancy, life births as well as recurrence for women with cervical cancer stage IB2 treated with either NACT followed by VRT, or ART.

Methods: A systematic review was performed using the PubMed database. Articles reporting the search term 'trachelectomy' as text word or as Medical Subject Headings (MeSH) were identified.

Results: Ten studies were identified with a total of 338 patients. After NACT followed by VRT 39% of the women tried to conceive, 70% of these women got pregnant, of which 63% resulted in a life birth. The overall recurrence and death rate were 10% and 2.9% respectively. After ART 40% of the women tried to conceive, 21% of these women got pregnant, which resulted in a life birth rate of 42%. Recurrence and death rate after ART were 6.9%, and 3.4% respectively.

Conclusion: Women with cervical cancer stage IB2 and a wish to preserve fertility treated with NACT followed by VRT have a significantly higher chance of pregnancy than women treated with ART, with comparative oncological results. (C) 2019 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalGynecologic Oncology
Volume155
Issue number3
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Cervical cancer
  • Abdominal trachelectomy
  • Vaginal trachelectomy
  • Neoadjuvant chemotherapy
  • Pregnancy
  • Recurrence
  • DENSITY NEOADJUVANT CHEMOTHERAPY
  • VASCULAR SPACE INVASION
  • SQUAMOUS CANCER
  • WOMEN
  • SURGERY
  • QUANTITY
  • OUTCOMES
  • RISK
  • CM

Cite this