Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer.: A systematic review on fertility and recurrence rates

K. G. G. van Kol; T. F. M. Vergeldt; R. L. M. Bekkers

doi:10.1016/j.ygyno.2019.09.025

Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates

K. G. G. van Kol^*, T. F. M. Vergeldt, R. L. M. Bekkers

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Introduction: There is currently no standard of care for women with cervical cancer stage IB2 (FIGO 2018, >= 2 cm and

Objective: To compare rates of fertility, pregnancy, life births as well as recurrence for women with cervical cancer stage IB2 treated with either NACT followed by VRT, or ART.

Methods: A systematic review was performed using the PubMed database. Articles reporting the search term 'trachelectomy' as text word or as Medical Subject Headings (MeSH) were identified.

Results: Ten studies were identified with a total of 338 patients. After NACT followed by VRT 39% of the women tried to conceive, 70% of these women got pregnant, of which 63% resulted in a life birth. The overall recurrence and death rate were 10% and 2.9% respectively. After ART 40% of the women tried to conceive, 21% of these women got pregnant, which resulted in a life birth rate of 42%. Recurrence and death rate after ART were 6.9%, and 3.4% respectively.

Conclusion: Women with cervical cancer stage IB2 and a wish to preserve fertility treated with NACT followed by VRT have a significantly higher chance of pregnancy than women treated with ART, with comparative oncological results. (C) 2019 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	515-521
Number of pages	7
Journal	Gynecologic Oncology
Volume	155
Issue number	3
DOIs	https://doi.org/10.1016/j.ygyno.2019.09.025
Publication status	Published - Dec 2019

Keywords

Cervical cancer
Abdominal trachelectomy
Vaginal trachelectomy
Neoadjuvant chemotherapy
Pregnancy
Recurrence
DENSITY NEOADJUVANT CHEMOTHERAPY
VASCULAR SPACE INVASION
SQUAMOUS CANCER
WOMEN
SURGERY
QUANTITY
OUTCOMES
RISK
CM

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10.1016/j.ygyno.2019.09.025

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@article{093968b4427c430e86f7a8e33682b064,

title = "Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer.: A systematic review on fertility and recurrence rates",

abstract = "Introduction: There is currently no standard of care for women with cervical cancer stage IB2 (FIGO 2018, >= 2 cm andObjective: To compare rates of fertility, pregnancy, life births as well as recurrence for women with cervical cancer stage IB2 treated with either NACT followed by VRT, or ART.Methods: A systematic review was performed using the PubMed database. Articles reporting the search term 'trachelectomy' as text word or as Medical Subject Headings (MeSH) were identified.Results: Ten studies were identified with a total of 338 patients. After NACT followed by VRT 39% of the women tried to conceive, 70% of these women got pregnant, of which 63% resulted in a life birth. The overall recurrence and death rate were 10% and 2.9% respectively. After ART 40% of the women tried to conceive, 21% of these women got pregnant, which resulted in a life birth rate of 42%. Recurrence and death rate after ART were 6.9%, and 3.4% respectively.Conclusion: Women with cervical cancer stage IB2 and a wish to preserve fertility treated with NACT followed by VRT have a significantly higher chance of pregnancy than women treated with ART, with comparative oncological results. (C) 2019 Elsevier Inc. All rights reserved.",

keywords = "Cervical cancer, Abdominal trachelectomy, Vaginal trachelectomy, Neoadjuvant chemotherapy, Pregnancy, Recurrence, DENSITY NEOADJUVANT CHEMOTHERAPY, VASCULAR SPACE INVASION, SQUAMOUS CANCER, WOMEN, SURGERY, QUANTITY, OUTCOMES, RISK, CM",

author = "{van Kol}, {K. G. G.} and Vergeldt, {T. F. M.} and Bekkers, {R. L. M.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

doi = "10.1016/j.ygyno.2019.09.025",

language = "English",

volume = "155",

pages = "515--521",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press Inc.",

number = "3",

}

Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates. / van Kol, K. G. G.; Vergeldt, T. F. M.; Bekkers, R. L. M.
In: Gynecologic Oncology, Vol. 155, No. 3, 12.2019, p. 515-521.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer.

T2 - A systematic review on fertility and recurrence rates

AU - van Kol, K. G. G.

AU - Vergeldt, T. F. M.

AU - Bekkers, R. L. M.

PY - 2019/12

Y1 - 2019/12

N2 - Introduction: There is currently no standard of care for women with cervical cancer stage IB2 (FIGO 2018, >= 2 cm andObjective: To compare rates of fertility, pregnancy, life births as well as recurrence for women with cervical cancer stage IB2 treated with either NACT followed by VRT, or ART.Methods: A systematic review was performed using the PubMed database. Articles reporting the search term 'trachelectomy' as text word or as Medical Subject Headings (MeSH) were identified.Results: Ten studies were identified with a total of 338 patients. After NACT followed by VRT 39% of the women tried to conceive, 70% of these women got pregnant, of which 63% resulted in a life birth. The overall recurrence and death rate were 10% and 2.9% respectively. After ART 40% of the women tried to conceive, 21% of these women got pregnant, which resulted in a life birth rate of 42%. Recurrence and death rate after ART were 6.9%, and 3.4% respectively.Conclusion: Women with cervical cancer stage IB2 and a wish to preserve fertility treated with NACT followed by VRT have a significantly higher chance of pregnancy than women treated with ART, with comparative oncological results. (C) 2019 Elsevier Inc. All rights reserved.

AB - Introduction: There is currently no standard of care for women with cervical cancer stage IB2 (FIGO 2018, >= 2 cm andObjective: To compare rates of fertility, pregnancy, life births as well as recurrence for women with cervical cancer stage IB2 treated with either NACT followed by VRT, or ART.Methods: A systematic review was performed using the PubMed database. Articles reporting the search term 'trachelectomy' as text word or as Medical Subject Headings (MeSH) were identified.Results: Ten studies were identified with a total of 338 patients. After NACT followed by VRT 39% of the women tried to conceive, 70% of these women got pregnant, of which 63% resulted in a life birth. The overall recurrence and death rate were 10% and 2.9% respectively. After ART 40% of the women tried to conceive, 21% of these women got pregnant, which resulted in a life birth rate of 42%. Recurrence and death rate after ART were 6.9%, and 3.4% respectively.Conclusion: Women with cervical cancer stage IB2 and a wish to preserve fertility treated with NACT followed by VRT have a significantly higher chance of pregnancy than women treated with ART, with comparative oncological results. (C) 2019 Elsevier Inc. All rights reserved.

KW - Cervical cancer

KW - Abdominal trachelectomy

KW - Vaginal trachelectomy

KW - Neoadjuvant chemotherapy

KW - Pregnancy

KW - Recurrence

KW - DENSITY NEOADJUVANT CHEMOTHERAPY

KW - VASCULAR SPACE INVASION

KW - SQUAMOUS CANCER

KW - WOMEN

KW - SURGERY

KW - QUANTITY

KW - OUTCOMES

KW - RISK

KW - CM

U2 - 10.1016/j.ygyno.2019.09.025

DO - 10.1016/j.ygyno.2019.09.025

M3 - (Systematic) Review article

C2 - 31606284

SN - 0090-8258

VL - 155

SP - 515

EP - 521

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 3

ER -

Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates

Abstract

Keywords

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