TY - JOUR
T1 - Abdominal and gluteofemoral fat depots show opposing associations with postprandial lipemia
AU - Christiansen, M.R.
AU - Urena, M.G.
AU - Borisevich, D.
AU - Grarup, N.
AU - Martinez, J.A.
AU - Oppert, J.M.
AU - Sorensen, T.I.A.
AU - Hansen, T.
AU - Blaak, E.E.
AU - Kilpelainen, T.O.
N1 - Funding Information:
Supported by a Danish Diabetes Academy research grant from a Novo Nordisk Foundation (NNF) grant NNF17SA0031406 (to MRC), NNF grantNNF20OC0063707 (to TOK), and NNF Copenhagen Bioscience PhD Programme grant NNF17CC0026760 (to DB). Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center based at the University of Copenhagen, partially funded by an unconditional donation from the NNF, grant NNF18CC0034900.
Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background: High postprandial lipemia is associated with increased risk of cardiovascular disease, independently of fasting lipid concentrations. Abdominal and gluteofemoral fat depots handle lipoproteins differently, which could affect postprandial lipemia and contribute to the relation between abdominal fat distribution and cardiovascular disease risk.Objectives: We aimed to study the influences of higher abdominal compared with gluteofemoral fat on postprandial lipemia after a high-fat meal in individuals with obesity.Methods: A total of 755 adults with obesity from a randomized controlled trial in 7 European countries consumed a liquid high-fat meal. Concentrations of triglycerides (TG), glycerol, free fatty acids, and the cholesterol component of remnant-like particles (RLP), LDL, and HDL were measured postprandially for 3 h. Associations of waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR) with changes in postprandial lipid concentrations. adjusted for fasting concentrations and BMI, were examined using linear regression models. To assess whether the association of WHR with postprandial lipemia could be causal, we performed instrumental variable analyses using a genetic score of 442 variants known to be associated with WHR adjusted for BMI in 2-stage least-squares regression models.Results: WHR was associated with higher TG and RLP cholesterol concentrations, independent of fasting lipid concentrations and BMI. Instrumental variable analyses suggested that the associations of WIIR with postprandial TG (beta = 0.038 mu mol/L*min, SE = 0.019 mu mol/L*min, P = 0.044) and RLP cholesterol concentrations (beta = 0.059 mmol/L, SE = 0.025 mmol/L, P = 0.020) may be causal. WC and HC showed opposite effects: higher WC was associated with higher TG and RLP cholesterol concentrations whereas higher HC was associated with lower concentrations.Conclusions: Our results suggest that higher fat deposition abdominally versus gluteofemorally may be causally associated with elevated postprandial lipemia after a high-fat meal, independent of fasting lipid concentrations and BMI. Furthermore, higher abdominal and gluteofemoral fat depots show opposing effects on postprandial lipemia.
AB - Background: High postprandial lipemia is associated with increased risk of cardiovascular disease, independently of fasting lipid concentrations. Abdominal and gluteofemoral fat depots handle lipoproteins differently, which could affect postprandial lipemia and contribute to the relation between abdominal fat distribution and cardiovascular disease risk.Objectives: We aimed to study the influences of higher abdominal compared with gluteofemoral fat on postprandial lipemia after a high-fat meal in individuals with obesity.Methods: A total of 755 adults with obesity from a randomized controlled trial in 7 European countries consumed a liquid high-fat meal. Concentrations of triglycerides (TG), glycerol, free fatty acids, and the cholesterol component of remnant-like particles (RLP), LDL, and HDL were measured postprandially for 3 h. Associations of waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR) with changes in postprandial lipid concentrations. adjusted for fasting concentrations and BMI, were examined using linear regression models. To assess whether the association of WHR with postprandial lipemia could be causal, we performed instrumental variable analyses using a genetic score of 442 variants known to be associated with WHR adjusted for BMI in 2-stage least-squares regression models.Results: WHR was associated with higher TG and RLP cholesterol concentrations, independent of fasting lipid concentrations and BMI. Instrumental variable analyses suggested that the associations of WIIR with postprandial TG (beta = 0.038 mu mol/L*min, SE = 0.019 mu mol/L*min, P = 0.044) and RLP cholesterol concentrations (beta = 0.059 mmol/L, SE = 0.025 mmol/L, P = 0.020) may be causal. WC and HC showed opposite effects: higher WC was associated with higher TG and RLP cholesterol concentrations whereas higher HC was associated with lower concentrations.Conclusions: Our results suggest that higher fat deposition abdominally versus gluteofemorally may be causally associated with elevated postprandial lipemia after a high-fat meal, independent of fasting lipid concentrations and BMI. Furthermore, higher abdominal and gluteofemoral fat depots show opposing effects on postprandial lipemia.
KW - body fat distribution
KW - postprandial lipemia
KW - genetic association study
KW - Mendelian randomization
KW - oral fat tolerance test (OFFT)
KW - BODY-FAT
KW - MENDELIAN RANDOMIZATION
KW - CARDIOVASCULAR EVENTS
KW - HIP CIRCUMFERENCES
KW - HEART-DISEASE
KW - TRUNK FAT
KW - RISK
KW - WAIST
KW - TRIGLYCERIDES
KW - OXIDATION
U2 - 10.1093/ajcn/nqab219
DO - 10.1093/ajcn/nqab219
M3 - Article
C2 - 34254976
SN - 0002-9165
VL - 114
SP - 1467
EP - 1475
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 4
ER -