Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

Melinda Barkhuizen; Johan S. H. Vles; Ralph van Mechelen; Marijne Vermeer; Boris W. Kramer; Peter Chedraui; Paul Bergs; Vivianne H. J. M. van Kranen-Mastenbroek; Antonio W. D. Gavilanes

doi:10.3390/diagnostics9030123

Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

Melinda Barkhuizen^*, Johan S. H. Vles, Ralph van Mechelen, Marijne Vermeer, Boris W. Kramer, Peter Chedraui, Paul Bergs, Vivianne H. J. M. van Kranen-Mastenbroek, Antonio W. D. Gavilanes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.

Original language	English
Article number	123
Number of pages	8
Journal	Diagnostics
Volume	9
Issue number	3
DOIs	https://doi.org/10.3390/diagnostics9030123
Publication status	Published - Sept 2019

Keywords

somatosensory evoked potential
preterm brain
rat model
cerebral palsy
hypoxia-ischemia
BEHAVIORAL CONSEQUENCES
SPINAL-CORD
ASPHYXIA
DEFICITS
CHILDREN
INJURY

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10.3390/diagnostics9030123Licence: CC BY

Cite this

@article{a908a6f7cfb24056bfdb7d1c8ac75bac,

title = "Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats",

abstract = "Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.",

keywords = "somatosensory evoked potential, preterm brain, rat model, cerebral palsy, hypoxia-ischemia, BEHAVIORAL CONSEQUENCES, SPINAL-CORD, ASPHYXIA, DEFICITS, CHILDREN, INJURY",

author = "Melinda Barkhuizen and Vles, {Johan S. H.} and {van Mechelen}, Ralph and Marijne Vermeer and Kramer, {Boris W.} and Peter Chedraui and Paul Bergs and {van Kranen-Mastenbroek}, {Vivianne H. J. M.} and Gavilanes, {Antonio W. D.}",

note = "Funding Information: This research was partially supported by the Sistema de Investigaci{\'o}n y Desarrollo (SINDE) of the Universidad Cat{\'o}lica de Santiago de Guayaquil, Guayaquil, Ecuador, through the grant No SIU- 319: Perinatal asphyxia and stem cell treatment. M. Barkhuizen is funded by the National Research Foundation of South Africa (Grant specific reference number 89230 and 98217) and the Foundation of Paediatrics, Maastricht University Medical Centre +. All views expressed in this article are those of the authors and not of the funding agencies. Publisher Copyright: {\textcopyright} 2019 by the authors.",

year = "2019",

month = sep,

doi = "10.3390/diagnostics9030123",

language = "English",

volume = "9",

journal = "Diagnostics",

publisher = "MDPI",

number = "3",

}

TY - JOUR

T1 - Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

AU - Barkhuizen, Melinda

AU - Vles, Johan S. H.

AU - van Mechelen, Ralph

AU - Vermeer, Marijne

AU - Kramer, Boris W.

AU - Chedraui, Peter

AU - Bergs, Paul

AU - van Kranen-Mastenbroek, Vivianne H. J. M.

AU - Gavilanes, Antonio W. D.

N1 - Funding Information: This research was partially supported by the Sistema de Investigación y Desarrollo (SINDE) of the Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador, through the grant No SIU- 319: Perinatal asphyxia and stem cell treatment. M. Barkhuizen is funded by the National Research Foundation of South Africa (Grant specific reference number 89230 and 98217) and the Foundation of Paediatrics, Maastricht University Medical Centre +. All views expressed in this article are those of the authors and not of the funding agencies. Publisher Copyright: © 2019 by the authors.

PY - 2019/9

Y1 - 2019/9

N2 - Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.

AB - Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.

KW - somatosensory evoked potential

KW - preterm brain

KW - rat model

KW - cerebral palsy

KW - hypoxia-ischemia

KW - BEHAVIORAL CONSEQUENCES

KW - SPINAL-CORD

KW - ASPHYXIA

KW - DEFICITS

KW - CHILDREN

KW - INJURY

U2 - 10.3390/diagnostics9030123

DO - 10.3390/diagnostics9030123

M3 - Article

C2 - 31540369

VL - 9

JO - Diagnostics

JF - Diagnostics

IS - 3

M1 - 123

ER -