A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?

A. Mobasheri*, A. Mahmoudian, U. Kalvaityte, I. Uzieliene, C.E. Larder, M.M. Iskandar, S. Kubow, P.C. Hamdan, C.S. de Almeida, L.J. Favazzo, L.J.C. van Loon, P.J. Emans, P.G. Plapler, M.J. Zuscik*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose of Review Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure. Recent Findings This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
Original languageEnglish
Article number78
Number of pages15
JournalCurrent Rheumatology Reports
Issue number11
Publication statusPublished - 1 Nov 2021


  • Joint health
  • Osteoarthritis
  • Nutritional supplement
  • Nutraceutical
  • Denatured collagen
  • Collagen hydrolyzate
  • Collagen ultra-hydrolyzate
  • UC-II
  • FOOD

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