A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm

Declan T. Bradley; Anne E. Hughes; Stephen A. Badger; Gregory T Jones; Seamus C. Harrison; Benjamin J. Wright; Suzannah J. Bumpstead; Annette F. Baas; Solveig Gretarsdottir; Kevin Burnand; Anne H. Child; Rachel E. Clough; Gillian Cockerill; Hany Hafez; D. Julian A. Scott; Robert A. S. Ariens; Anne Johnson; Soroush Sohrabi; Alberto Smith; Matthew Thompson; Frank M. van Bockxmeer; Matthew Waltham; Stefan E Matthiasson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jan D. Blankensteijn; Joep A. W. Teijink; Cisca Wijmenga; Jacqueline de Graaf; Lambertus A. Kiemeney; John B. Wild; Sarah Edkins; Rhian Gwilliam; Sarah E. Hunt; Simon C. Potter; Jes S Lindholt; Jonathan Golledge; Paul E. Norman; Andre M van Rij; Janet T. Powell; Per Eriksson; Kari Stefansson; John R Thompson; Steve E. Humphries; Robert D. Sayers; Panos Deloukas; Nilesh J. Samani; Matthew J. Bown

doi:10.1161/CIRCGENETICS.113.000165

A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm

Declan T. Bradley^*, Anne E. Hughes, Stephen A. Badger, Gregory T Jones, Seamus C. Harrison, Benjamin J. Wright, Suzannah J. Bumpstead, Annette F. Baas, Solveig Gretarsdottir, Kevin Burnand, Anne H. Child, Rachel E. Clough, Gillian Cockerill, Hany Hafez, D. Julian A. Scott, Robert A. S. Ariens, Anne Johnson, Soroush Sohrabi, Alberto Smith, Matthew ThompsonFrank M. van Bockxmeer, Matthew Waltham, Stefan E Matthiasson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jan D. Blankensteijn, Joep A. W. Teijink, Cisca Wijmenga, Jacqueline de Graaf, Lambertus A. Kiemeney, John B. Wild, Sarah Edkins, Rhian Gwilliam, Sarah E. Hunt, Simon C. Potter, Jes S Lindholt, Jonathan Golledge, Paul E. Norman, Andre M van Rij, Janet T. Powell, Per Eriksson, Kari Stefansson, John R Thompson, Steve E. Humphries, Robert D. Sayers, Panos Deloukas, Nilesh J. Samani, Matthew J. Bown

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance.A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter?30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P

Original language	English
Pages (from-to)	498-504
Journal	Circulation : Cardiovascular Genetics
Volume	6
Issue number	5
DOIs	https://doi.org/10.1161/CIRCGENETICS.113.000165
Publication status	Published - Oct 2013

Keywords

aneurysm
cholesterol
LDL
genome-wide association study
lipids

Access to Document

10.1161/CIRCGENETICS.113.000165

Cite this

Bradley, D. T., Hughes, A. E., Badger, S. A., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S. J., Baas, A. F., Gretarsdottir, S., Burnand, K., Child, A. H., Clough, R. E., Cockerill, G., Hafez, H., Scott, D. J. A., Ariens, R. A. S., Johnson, A., Sohrabi, S., Smith, A., ... Bown, M. J. (2013). A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm. Circulation : Cardiovascular Genetics, 6(5), 498-504. https://doi.org/10.1161/CIRCGENETICS.113.000165

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title = "A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm",

abstract = "Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance.A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter?30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P",

keywords = "aneurysm, cholesterol, LDL, genome-wide association study, lipids",

author = "Bradley, {Declan T.} and Hughes, {Anne E.} and Badger, {Stephen A.} and Jones, {Gregory T} and Harrison, {Seamus C.} and Wright, {Benjamin J.} and Bumpstead, {Suzannah J.} and Baas, {Annette F.} and Solveig Gretarsdottir and Kevin Burnand and Child, {Anne H.} and Clough, {Rachel E.} and Gillian Cockerill and Hany Hafez and Scott, {D. Julian A.} and Ariens, {Robert A. S.} and Anne Johnson and Soroush Sohrabi and Alberto Smith and Matthew Thompson and {van Bockxmeer}, {Frank M.} and Matthew Waltham and Matthiasson, {Stefan E} and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Blankensteijn, {Jan D.} and Teijink, {Joep A. W.} and Cisca Wijmenga and {de Graaf}, Jacqueline and Kiemeney, {Lambertus A.} and Wild, {John B.} and Sarah Edkins and Rhian Gwilliam and Hunt, {Sarah E.} and Potter, {Simon C.} and Lindholt, {Jes S} and Jonathan Golledge and Norman, {Paul E.} and {van Rij}, {Andre M} and Powell, {Janet T.} and Per Eriksson and Kari Stefansson and Thompson, {John R} and Humphries, {Steve E.} and Sayers, {Robert D.} and Panos Deloukas and Samani, {Nilesh J.} and Bown, {Matthew J.}",

year = "2013",

month = oct,

doi = "10.1161/CIRCGENETICS.113.000165",

language = "English",

volume = "6",

pages = "498--504",

journal = "Circulation : Cardiovascular Genetics",

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publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "5",

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Bradley, DT, Hughes, AE, Badger, SA, Jones, GT, Harrison, SC, Wright, BJ, Bumpstead, SJ, Baas, AF, Gretarsdottir, S, Burnand, K, Child, AH, Clough, RE, Cockerill, G, Hafez, H, Scott, DJA, Ariens, RAS, Johnson, A, Sohrabi, S, Smith, A, Thompson, M, van Bockxmeer, FM, Waltham, M, Matthiasson, SE, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, JD, Teijink, JAW, Wijmenga, C, de Graaf, J, Kiemeney, LA, Wild, JB, Edkins, S, Gwilliam, R, Hunt, SE, Potter, SC, Lindholt, JS, Golledge, J, Norman, PE, van Rij, AM, Powell, JT, Eriksson, P, Stefansson, K, Thompson, JR, Humphries, SE, Sayers, RD, Deloukas, P, Samani, NJ & Bown, MJ 2013, 'A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm', Circulation : Cardiovascular Genetics, vol. 6, no. 5, pp. 498-504. https://doi.org/10.1161/CIRCGENETICS.113.000165

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T1 - A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm

AU - Bradley, Declan T.

AU - Hughes, Anne E.

AU - Badger, Stephen A.

AU - Jones, Gregory T

AU - Harrison, Seamus C.

AU - Wright, Benjamin J.

AU - Bumpstead, Suzannah J.

AU - Baas, Annette F.

AU - Gretarsdottir, Solveig

AU - Burnand, Kevin

AU - Child, Anne H.

AU - Clough, Rachel E.

AU - Cockerill, Gillian

AU - Hafez, Hany

AU - Scott, D. Julian A.

AU - Ariens, Robert A. S.

AU - Johnson, Anne

AU - Sohrabi, Soroush

AU - Smith, Alberto

AU - Thompson, Matthew

AU - van Bockxmeer, Frank M.

AU - Waltham, Matthew

AU - Matthiasson, Stefan E

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Blankensteijn, Jan D.

AU - Teijink, Joep A. W.

AU - Wijmenga, Cisca

AU - de Graaf, Jacqueline

AU - Kiemeney, Lambertus A.

AU - Wild, John B.

AU - Edkins, Sarah

AU - Gwilliam, Rhian

AU - Hunt, Sarah E.

AU - Potter, Simon C.

AU - Lindholt, Jes S

AU - Golledge, Jonathan

AU - Norman, Paul E.

AU - van Rij, Andre M

AU - Powell, Janet T.

AU - Eriksson, Per

AU - Stefansson, Kari

AU - Thompson, John R

AU - Humphries, Steve E.

AU - Sayers, Robert D.

AU - Deloukas, Panos

AU - Samani, Nilesh J.

AU - Bown, Matthew J.

PY - 2013/10

Y1 - 2013/10

N2 - Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance.A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter?30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P

AB - Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance.A genome-wide association study was conducted using 1830 cases from the United Kingdom, New Zealand, and Australia with infrarenal aorta diameter?30 mm or ruptured AAA and 5435 unscreened controls from the 1958 Birth Cohort and National Blood Service cohort from the Wellcome Trust Case Control Consortium. Eight suggestive associations with P

KW - aneurysm

KW - cholesterol

KW - LDL

KW - genome-wide association study

KW - lipids

U2 - 10.1161/CIRCGENETICS.113.000165

DO - 10.1161/CIRCGENETICS.113.000165

M3 - Article

C2 - 24046328

SN - 1942-3268

VL - 6

SP - 498

EP - 504

JO - Circulation : Cardiovascular Genetics

JF - Circulation : Cardiovascular Genetics

IS - 5

ER -