A two-phenotype model of immune evasion by cancer cells

Peter Bayer*, Joel S. Brown, Katerina Stankova

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We propose a model with two types of cancer cells differentiated by their defense mechanisms against the immune system. “selfish” cancer cells develop defense mechanisms that benefit the individual cell, whereas “cooperative” cells deploy countermeasures that increase the chance of survival of every cell. Our phenotypes capture the two main features of the tumor’s efforts to avoid immune destruction, crypticity against immune cells for the selfish cells, and tumor-induced immunosuppression for the cooperative cells. We identify steady states of the system and show that only homogeneous tumors can be stable in both size and composition. We show that under generic parameter values, a tumor of selfish cells is more benign than a tumor of cooperative cells, and that a treatment against cancer crypticity may promote immunosuppression and increase cancer growth.
Original languageEnglish
Pages (from-to)191-204
Number of pages14
JournalJournal of Theoretical Biology
Volume455
DOIs
Publication statusPublished - 14 Oct 2018

Keywords

  • Cancer heterogeneity
  • Cancer ecology and evolution
  • Immunoediting
  • Immunosuppression
  • Immunotherapy
  • MATHEMATICAL-MODEL
  • TUMOR-GROWTH
  • BIOLOGICAL INVASIONS
  • DRUG-RESISTANCE
  • DOWN-REGULATION
  • NECROTIC CORE
  • IMMUNOTHERAPY
  • ANTIGEN
  • TRANSPORTER
  • DYNAMICS

Cite this

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title = "A two-phenotype model of immune evasion by cancer cells",
abstract = "We propose a model with two types of cancer cells differentiated by their defense mechanisms against the immune system. “selfish” cancer cells develop defense mechanisms that benefit the individual cell, whereas “cooperative” cells deploy countermeasures that increase the chance of survival of every cell. Our phenotypes capture the two main features of the tumor’s efforts to avoid immune destruction, crypticity against immune cells for the selfish cells, and tumor-induced immunosuppression for the cooperative cells. We identify steady states of the system and show that only homogeneous tumors can be stable in both size and composition. We show that under generic parameter values, a tumor of selfish cells is more benign than a tumor of cooperative cells, and that a treatment against cancer crypticity may promote immunosuppression and increase cancer growth.",
keywords = "Cancer heterogeneity, Cancer ecology and evolution, Immunoediting, Immunosuppression, Immunotherapy, MATHEMATICAL-MODEL, TUMOR-GROWTH, BIOLOGICAL INVASIONS, DRUG-RESISTANCE, DOWN-REGULATION, NECROTIC CORE, IMMUNOTHERAPY, ANTIGEN, TRANSPORTER, DYNAMICS",
author = "Peter Bayer and Brown, {Joel S.} and Katerina Stankova",
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year = "2018",
month = "10",
day = "14",
doi = "10.1016/j.jtbi.2018.07.014",
language = "English",
volume = "455",
pages = "191--204",
journal = "Journal of Theoretical Biology",
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}

A two-phenotype model of immune evasion by cancer cells. / Bayer, Peter; Brown, Joel S.; Stankova, Katerina.

In: Journal of Theoretical Biology, Vol. 455, 14.10.2018, p. 191-204.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A two-phenotype model of immune evasion by cancer cells

AU - Bayer, Peter

AU - Brown, Joel S.

AU - Stankova, Katerina

N1 - data source: no data used

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Y1 - 2018/10/14

N2 - We propose a model with two types of cancer cells differentiated by their defense mechanisms against the immune system. “selfish” cancer cells develop defense mechanisms that benefit the individual cell, whereas “cooperative” cells deploy countermeasures that increase the chance of survival of every cell. Our phenotypes capture the two main features of the tumor’s efforts to avoid immune destruction, crypticity against immune cells for the selfish cells, and tumor-induced immunosuppression for the cooperative cells. We identify steady states of the system and show that only homogeneous tumors can be stable in both size and composition. We show that under generic parameter values, a tumor of selfish cells is more benign than a tumor of cooperative cells, and that a treatment against cancer crypticity may promote immunosuppression and increase cancer growth.

AB - We propose a model with two types of cancer cells differentiated by their defense mechanisms against the immune system. “selfish” cancer cells develop defense mechanisms that benefit the individual cell, whereas “cooperative” cells deploy countermeasures that increase the chance of survival of every cell. Our phenotypes capture the two main features of the tumor’s efforts to avoid immune destruction, crypticity against immune cells for the selfish cells, and tumor-induced immunosuppression for the cooperative cells. We identify steady states of the system and show that only homogeneous tumors can be stable in both size and composition. We show that under generic parameter values, a tumor of selfish cells is more benign than a tumor of cooperative cells, and that a treatment against cancer crypticity may promote immunosuppression and increase cancer growth.

KW - Cancer heterogeneity

KW - Cancer ecology and evolution

KW - Immunoediting

KW - Immunosuppression

KW - Immunotherapy

KW - MATHEMATICAL-MODEL

KW - TUMOR-GROWTH

KW - BIOLOGICAL INVASIONS

KW - DRUG-RESISTANCE

KW - DOWN-REGULATION

KW - NECROTIC CORE

KW - IMMUNOTHERAPY

KW - ANTIGEN

KW - TRANSPORTER

KW - DYNAMICS

U2 - 10.1016/j.jtbi.2018.07.014

DO - 10.1016/j.jtbi.2018.07.014

M3 - Article

VL - 455

SP - 191

EP - 204

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

ER -