A systematic review of the prognostic value of motor abnormalities on clinical outcome in psychosis

Lydia E Pieters, Niluja Nadesalingam, Sebastian Walther, Peter N van Harten*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Web of Science)
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Abstract

Schizophrenia spectrum disorders have heterogeneous outcomes and currently no marker predicts the course of illness. Motor abnormalities (MAs) are inherent to psychosis, the risk of psychosis, symptom severity, and brain alterations. However, the prognostic value of MAs is still unresolved. Here, we provide a systematic review of longitudinal studies on the prognostic role of MAs spanning individuals at clinical high risk for psychosis (CHR), patients with first-episode psychosis (FEP), and chronic schizophrenia. We included 68 studies for a total of 23,630 subjects that assessed neurological soft signs (NSS), hypo- or hyperkinetic movement disorders and/or catatonia as a prognostic factor on clinical and functional outcomes. We found increased levels of MAs, in particular NSS, parkinsonism, and dyskinesia, were related to deteriorating symptomatic and poor functional outcome over time. Collectively, the findings emphasize the clinical, prognostic and scientific relevance of MA assessment and detection in individuals with or at risk of psychosis. In the future, instrumental measures of MA are expected to further augment detection, early intervention and treatment strategies in psychosis.

Original languageEnglish
Pages (from-to)691-705
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume132
Early online date20 Nov 2021
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Movement disorders
  • Motor abnormalities
  • Psychosis
  • Schizophrenia
  • Prognosis
  • NEUROLOGICAL SOFT SIGNS
  • ANTIPSYCHOTIC-NAIVE PATIENTS
  • RISK MENTAL STATE
  • TARDIVE-DYSKINESIA
  • 1ST-EPISODE SCHIZOPHRENIA
  • NEGATIVE SYMPTOMS
  • MOVEMENT ABNORMALITIES
  • SENSORIMOTOR ABNORMALITIES
  • EXTRAPYRAMIDAL SYMPTOMS
  • PSYCHIATRIC-SYMPTOMS

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