The aetiology of childhood asthma is complex. An early dysfunction in immunological development of the innate immune system in combination environmental factors possibly triggers asthma. CD14 and toll-like important components of the innate immune system. The aim of this review was to obtain a better insight into the relation between CD14 and toll-like receptors and childhood asthma in Caucasians. We searched EMBASE for relevant articles. In total, 44 articles were included. The the selected studies was independently assessed by the first two authors the Newcastle-Ottawa quality assessment scale. Toll-like receptor 2, receptor 6, toll-like receptor 9, and toll-like receptor 10 appear to association with childhood asthma in Caucasians. The evidence for a CD14 with childhood asthma is limited. In conclusion, there is no evidence yet for a role of CD14 and toll-like receptors in relation to asthma. Future studies should include haplotype analysis and take factors into account to further clarify the role of CD14 and toll-like on childhood asthma.