A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

M.V. Uthaug; R Lancelotta; K. van Oorsouw; K.P.C. Kuypers; N. Mason; J Rak; A Šuláková; R Jurok; M Maryška; M Kuchař; T Páleníček; J. Riba; J.G. Ramaekers

doi:10.1007/s00213-019-05236-w

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

M.V. Uthaug^*, R Lancelotta, K. van Oorsouw, K.P.C. Kuypers, N. Mason, J Rak, A Šuláková, R Jurok, M Maryška, M Kuchař, T Páleníček, J. Riba, J.G. Ramaekers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.

AIMS: The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience.

METHODS: Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations.

RESULTS: Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress.

CONCLUSION: A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.

Original language	English
Pages (from-to)	2653–2666
Number of pages	14
Journal	Psychopharmacology
Volume	236
Issue number	9
Early online date	13 Apr 2019
DOIs	https://doi.org/10.1007/s00213-019-05236-w
Publication status	Published - Sept 2019

Keywords

5-MeO-DMT
ANXIETY
AYAHUASCA
Affect
Altered states of consciousness
Bufo alvarius
Cognition
DEPRESSION
Field study
HALLUCINOGEN
PHARMACOLOGY
PSILOCYBIN
PSYCHEDELICS
Psychedelic
Satisfaction with life
THREATENING CANCER
VALIDATION

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Uthaug, M. V., Lancelotta, R., van Oorsouw, K., Kuypers, K. P. C., Mason, N., Rak, J., Šuláková, A., Jurok, R., Maryška, M., Kuchař, M., Páleníček, T., Riba, J., & Ramaekers, J. G. (2019). A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology, 236(9), 2653–2666. https://doi.org/10.1007/s00213-019-05236-w

Uthaug, M.V. ; Lancelotta, R ; van Oorsouw, K. et al. / A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. In: Psychopharmacology. 2019 ; Vol. 236, No. 9. pp. 2653–2666.

@article{46ae6a06926c4771bccb97783f2a964e,

title = "A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms",

abstract = "BACKGROUND: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.AIMS: The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience.METHODS: Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations.RESULTS: Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress.CONCLUSION: A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.",

keywords = "5-MeO-DMT, ANXIETY, AYAHUASCA, Affect, Altered states of consciousness, Bufo alvarius, Cognition, DEPRESSION, Field study, HALLUCINOGEN, PHARMACOLOGY, PSILOCYBIN, PSYCHEDELICS, Psychedelic, Satisfaction with life, THREATENING CANCER, VALIDATION",

author = "M.V. Uthaug and R Lancelotta and {van Oorsouw}, K. and K.P.C. Kuypers and N. Mason and J Rak and A {\v S}ul{\'a}kov{\'a} and R Jurok and M Mary{\v s}ka and M Kucha{\v r} and T P{\'a}len{\'i}{\v c}ek and J. Riba and J.G. Ramaekers",

note = "Funding Information: Funding information The analysis of the dried secretion from the Bufo Alvarius toad was supported by the projects VI20172020056 (Czech Ministry of Interior Affairs), grant LO1611 from the MEYS CR under the NPU I program (Czech Ministry of Education, Youth and Sports) and PROGRES Q35 (Charles University Prague). Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = sep,

doi = "10.1007/s00213-019-05236-w",

language = "English",

volume = "236",

pages = "2653–2666",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer",

number = "9",

}

Uthaug, MV, Lancelotta, R, van Oorsouw, K , Kuypers, KPC , Mason, N, Rak, J, Šuláková, A, Jurok, R, Maryška, M, Kuchař, M, Páleníček, T, Riba, J & Ramaekers, JG 2019, 'A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms', Psychopharmacology, vol. 236, no. 9, pp. 2653–2666. https://doi.org/10.1007/s00213-019-05236-w

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. / Uthaug, M.V.; Lancelotta, R; van Oorsouw, K. et al.
In: Psychopharmacology, Vol. 236, No. 9, 09.2019, p. 2653–2666.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

AU - Uthaug, M.V.

AU - Lancelotta, R

AU - van Oorsouw, K.

AU - Kuypers, K.P.C.

AU - Mason, N.

AU - Rak, J

AU - Šuláková, A

AU - Jurok, R

AU - Maryška, M

AU - Kuchař, M

AU - Páleníček, T

AU - Riba, J.

AU - Ramaekers, J.G.

N1 - Funding Information: Funding information The analysis of the dried secretion from the Bufo Alvarius toad was supported by the projects VI20172020056 (Czech Ministry of Interior Affairs), grant LO1611 from the MEYS CR under the NPU I program (Czech Ministry of Education, Youth and Sports) and PROGRES Q35 (Charles University Prague). Publisher Copyright: © 2019, The Author(s).

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.AIMS: The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience.METHODS: Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations.RESULTS: Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress.CONCLUSION: A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.

AB - BACKGROUND: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.AIMS: The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience.METHODS: Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations.RESULTS: Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress.CONCLUSION: A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.

KW - 5-MeO-DMT

KW - ANXIETY

KW - AYAHUASCA

KW - Affect

KW - Altered states of consciousness

KW - Bufo alvarius

KW - Cognition

KW - DEPRESSION

KW - Field study

KW - HALLUCINOGEN

KW - PHARMACOLOGY

KW - PSILOCYBIN

KW - PSYCHEDELICS

KW - Psychedelic

KW - Satisfaction with life

KW - THREATENING CANCER

KW - VALIDATION

U2 - 10.1007/s00213-019-05236-w

DO - 10.1007/s00213-019-05236-w

M3 - Article

C2 - 30982127

SN - 0033-3158

VL - 236

SP - 2653

EP - 2666

JO - Psychopharmacology

JF - Psychopharmacology

IS - 9

ER -

Uthaug MV, Lancelotta R, van Oorsouw K , Kuypers KPC , Mason N, Rak J et al. A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology. 2019 Sept;236(9):2653–2666. Epub 2019 Apr 13. doi: 10.1007/s00213-019-05236-w