A single dose of cocaine enhances prospective memory performance

Nadia RPW Hutten, Kim PC Kuypers, Janelle HP van Wel, Eef L Theunissen, Stefan W Toennes, Robbert-Jan Verkes, Johannes G Ramaekers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Prospective memory is the ability to recall intended actions or events at the right time or in the right context. While cannabis is known to impair prospective memory, the acute effect of cocaine is unknown. In addition, it is not clear whether changes in prospective memory represent specific alterations in memory processing or result from more general effects on cognition that spread across multiple domains such as arousal and attention.

AIMS: The main objective of the study was, therefore, to determine whether drug-induced changes in prospective memory are memory specific or associated with more general drug-induced changes in attention and arousal.

METHODS: A placebo-controlled, three-way, cross-over study including 15 regular poly-drug users was set up to test the influence of oral cocaine (300 mg) and vaporised cannabis (300+150 'booster' µg/kg bodyweight) on an event-based prospective memory task. Attentional performance was assessed using a divided attention task and subjective arousal was assessed with the Profile of Mood States questionnaire.

RESULTS: Results showed that cocaine enhanced prospective memory, attention and arousal. Mean performance of prospective memory and attention, as well as levels of arousal were lowest during treatment with cannabis as compared with placebo and cocaine as evinced by a significantly increased trend across treatment conditions. Prospective memory performance was only weakly positively associated to measures of attention and arousal.

CONCLUSION: Together, these results indicate that cocaine enhancement of prospective memory performance cannot be fully explained by parallel changes in arousal and attention levels, and is likely to represent a direct change in the neural network underlying prospective memory.

Original languageEnglish
Pages (from-to) 883–892
Number of pages10
JournalJournal of Psychopharmacology
Volume32
Issue number8
Early online date27 Jun 2018
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Journal Article
  • ATTENTION
  • delta-9-tetrahydrocannabinol
  • event-based
  • ORAL FLUID
  • CANNABIS
  • IMPAIRMENT
  • HEAVY
  • RETROSPECTIVE MEMORY
  • prospective memory
  • IMPULSE CONTROL
  • DRUGS
  • attention
  • METHYLPHENIDATE
  • Cocaine
  • VERBAL MEMORY

Cite this

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title = "A single dose of cocaine enhances prospective memory performance",
abstract = "BACKGROUND: Prospective memory is the ability to recall intended actions or events at the right time or in the right context. While cannabis is known to impair prospective memory, the acute effect of cocaine is unknown. In addition, it is not clear whether changes in prospective memory represent specific alterations in memory processing or result from more general effects on cognition that spread across multiple domains such as arousal and attention.AIMS: The main objective of the study was, therefore, to determine whether drug-induced changes in prospective memory are memory specific or associated with more general drug-induced changes in attention and arousal.METHODS: A placebo-controlled, three-way, cross-over study including 15 regular poly-drug users was set up to test the influence of oral cocaine (300 mg) and vaporised cannabis (300+150 'booster' µg/kg bodyweight) on an event-based prospective memory task. Attentional performance was assessed using a divided attention task and subjective arousal was assessed with the Profile of Mood States questionnaire.RESULTS: Results showed that cocaine enhanced prospective memory, attention and arousal. Mean performance of prospective memory and attention, as well as levels of arousal were lowest during treatment with cannabis as compared with placebo and cocaine as evinced by a significantly increased trend across treatment conditions. Prospective memory performance was only weakly positively associated to measures of attention and arousal.CONCLUSION: Together, these results indicate that cocaine enhancement of prospective memory performance cannot be fully explained by parallel changes in arousal and attention levels, and is likely to represent a direct change in the neural network underlying prospective memory.",
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author = "Hutten, {Nadia RPW} and Kuypers, {Kim PC} and {van Wel}, {Janelle HP} and Theunissen, {Eef L} and Toennes, {Stefan W} and Robbert-Jan Verkes and Ramaekers, {Johannes G}",
year = "2018",
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A single dose of cocaine enhances prospective memory performance. / Hutten, Nadia RPW; Kuypers, Kim PC; van Wel, Janelle HP; Theunissen, Eef L; Toennes, Stefan W; Verkes, Robbert-Jan; Ramaekers, Johannes G.

In: Journal of Psychopharmacology, Vol. 32, No. 8, 08.2018, p. 883–892.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A single dose of cocaine enhances prospective memory performance

AU - Hutten, Nadia RPW

AU - Kuypers, Kim PC

AU - van Wel, Janelle HP

AU - Theunissen, Eef L

AU - Toennes, Stefan W

AU - Verkes, Robbert-Jan

AU - Ramaekers, Johannes G

PY - 2018/8

Y1 - 2018/8

N2 - BACKGROUND: Prospective memory is the ability to recall intended actions or events at the right time or in the right context. While cannabis is known to impair prospective memory, the acute effect of cocaine is unknown. In addition, it is not clear whether changes in prospective memory represent specific alterations in memory processing or result from more general effects on cognition that spread across multiple domains such as arousal and attention.AIMS: The main objective of the study was, therefore, to determine whether drug-induced changes in prospective memory are memory specific or associated with more general drug-induced changes in attention and arousal.METHODS: A placebo-controlled, three-way, cross-over study including 15 regular poly-drug users was set up to test the influence of oral cocaine (300 mg) and vaporised cannabis (300+150 'booster' µg/kg bodyweight) on an event-based prospective memory task. Attentional performance was assessed using a divided attention task and subjective arousal was assessed with the Profile of Mood States questionnaire.RESULTS: Results showed that cocaine enhanced prospective memory, attention and arousal. Mean performance of prospective memory and attention, as well as levels of arousal were lowest during treatment with cannabis as compared with placebo and cocaine as evinced by a significantly increased trend across treatment conditions. Prospective memory performance was only weakly positively associated to measures of attention and arousal.CONCLUSION: Together, these results indicate that cocaine enhancement of prospective memory performance cannot be fully explained by parallel changes in arousal and attention levels, and is likely to represent a direct change in the neural network underlying prospective memory.

AB - BACKGROUND: Prospective memory is the ability to recall intended actions or events at the right time or in the right context. While cannabis is known to impair prospective memory, the acute effect of cocaine is unknown. In addition, it is not clear whether changes in prospective memory represent specific alterations in memory processing or result from more general effects on cognition that spread across multiple domains such as arousal and attention.AIMS: The main objective of the study was, therefore, to determine whether drug-induced changes in prospective memory are memory specific or associated with more general drug-induced changes in attention and arousal.METHODS: A placebo-controlled, three-way, cross-over study including 15 regular poly-drug users was set up to test the influence of oral cocaine (300 mg) and vaporised cannabis (300+150 'booster' µg/kg bodyweight) on an event-based prospective memory task. Attentional performance was assessed using a divided attention task and subjective arousal was assessed with the Profile of Mood States questionnaire.RESULTS: Results showed that cocaine enhanced prospective memory, attention and arousal. Mean performance of prospective memory and attention, as well as levels of arousal were lowest during treatment with cannabis as compared with placebo and cocaine as evinced by a significantly increased trend across treatment conditions. Prospective memory performance was only weakly positively associated to measures of attention and arousal.CONCLUSION: Together, these results indicate that cocaine enhancement of prospective memory performance cannot be fully explained by parallel changes in arousal and attention levels, and is likely to represent a direct change in the neural network underlying prospective memory.

KW - Journal Article

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KW - delta-9-tetrahydrocannabinol

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KW - ORAL FLUID

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KW - IMPAIRMENT

KW - HEAVY

KW - RETROSPECTIVE MEMORY

KW - prospective memory

KW - IMPULSE CONTROL

KW - DRUGS

KW - attention

KW - METHYLPHENIDATE

KW - Cocaine

KW - VERBAL MEMORY

U2 - 10.1177/0269881118783299

DO - 10.1177/0269881118783299

M3 - Article

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VL - 32

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JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

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ER -