A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels

Hoon Suk Rho; Henk Willem Veltkamp; Danielle Baptista; Séverine Le Gac; Pamela Habibovic

A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels

Hoon Suk Rho^*, Henk Willem Veltkamp, Danielle Baptista, Séverine Le Gac, Pamela Habibovic

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

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Abstract

We present a simple and robust microfabrication technique to create three-dimensional (3D) tapered polydimethylsiloxane (PDMS) channels. Tapered photoresist structures were fabricated by single-step lithography and thermal reflowing process, and the topography of the structures was controlled by varying design parameters, e.g., channel widths and length. Two half funnel-shaped PDMS replicas were combined to realize a 3D funnel-shaped PDMS structure. Human umbilical vein endothelial cells (HUVECs) were cultured in the 3D funnel channel to form an artificial vessel network. We believe that the 3D topographic structures with controlled curvatures would be useful in many scientific and engineering fields, including lab-on-a-chip devices and bio-inspired platforms.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Publisher	Chemical and Biological Microsystems Society
Pages	1156-1157
Number of pages	2
ISBN (Electronic)	9781733419000
Publication status	Published - 1 Jan 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	MicroTAS 2019
Country/Territory	Switzerland
City	Basel
Period	27/10/19 → 31/10/19

Keywords

3D tapered structure
Microfabrication
Thermal reflowing

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@inproceedings{c7964d4bdf06405d8f2b63efb5a2f2d6,

title = "A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels",

abstract = "We present a simple and robust microfabrication technique to create three-dimensional (3D) tapered polydimethylsiloxane (PDMS) channels. Tapered photoresist structures were fabricated by single-step lithography and thermal reflowing process, and the topography of the structures was controlled by varying design parameters, e.g., channel widths and length. Two half funnel-shaped PDMS replicas were combined to realize a 3D funnel-shaped PDMS structure. Human umbilical vein endothelial cells (HUVECs) were cultured in the 3D funnel channel to form an artificial vessel network. We believe that the 3D topographic structures with controlled curvatures would be useful in many scientific and engineering fields, including lab-on-a-chip devices and bio-inspired platforms.",

keywords = "3D tapered structure, Microfabrication, Thermal reflowing",

author = "Rho, {Hoon Suk} and Veltkamp, {Henk Willem} and Danielle Baptista and {Le Gac}, S{\'e}verine and Pamela Habibovic",

note = "Funding Information: P. Habibovic and H. S. RHO gratefully acknowledge financial supports from the Dutch Province of Limburg and Innovational Research Incentives Scheme Vidi (#15604) in the Netherlands Organization for Scientific Research (NWO). Publisher Copyright: {\textcopyright} 2019 CBMS-0001.; 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

year = "2019",

month = jan,

day = "1",

language = "English",

pages = "1156--1157",

booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019",

publisher = "Chemical and Biological Microsystems Society",

address = "United States",

}

Rho, HS, Veltkamp, HW, Baptista, D, Le Gac, S & Habibovic, P 2019, A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. Chemical and Biological Microsystems Society, pp. 1156-1157, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland, 27/10/19.

A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels. / Rho, Hoon Suk; Veltkamp, Henk Willem; Baptista, Danielle et al.
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. Chemical and Biological Microsystems Society, 2019. p. 1156-1157.

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

TY - GEN

T1 - A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels

AU - Rho, Hoon Suk

AU - Veltkamp, Henk Willem

AU - Baptista, Danielle

AU - Le Gac, Séverine

AU - Habibovic, Pamela

N1 - Conference code: 23

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We present a simple and robust microfabrication technique to create three-dimensional (3D) tapered polydimethylsiloxane (PDMS) channels. Tapered photoresist structures were fabricated by single-step lithography and thermal reflowing process, and the topography of the structures was controlled by varying design parameters, e.g., channel widths and length. Two half funnel-shaped PDMS replicas were combined to realize a 3D funnel-shaped PDMS structure. Human umbilical vein endothelial cells (HUVECs) were cultured in the 3D funnel channel to form an artificial vessel network. We believe that the 3D topographic structures with controlled curvatures would be useful in many scientific and engineering fields, including lab-on-a-chip devices and bio-inspired platforms.

AB - We present a simple and robust microfabrication technique to create three-dimensional (3D) tapered polydimethylsiloxane (PDMS) channels. Tapered photoresist structures were fabricated by single-step lithography and thermal reflowing process, and the topography of the structures was controlled by varying design parameters, e.g., channel widths and length. Two half funnel-shaped PDMS replicas were combined to realize a 3D funnel-shaped PDMS structure. Human umbilical vein endothelial cells (HUVECs) were cultured in the 3D funnel channel to form an artificial vessel network. We believe that the 3D topographic structures with controlled curvatures would be useful in many scientific and engineering fields, including lab-on-a-chip devices and bio-inspired platforms.

KW - 3D tapered structure

KW - Microfabrication

KW - Thermal reflowing

M3 - Conference article in proceeding

SP - 1156

EP - 1157

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

PB - Chemical and Biological Microsystems Society

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 27 October 2019 through 31 October 2019

ER -

A simple and robust fabrication method for creating 3d tapered polydimethylsiloxane channels

Abstract

Conference

Keywords

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