A simple analysis of a simple crossover trial with a dichotomous outcome measure

Hubert Schouten; Arnold D. Kester

doi:10.1002/sim.3771

A simple analysis of a simple crossover trial with a dichotomous outcome measure

Hubert Schouten, Arnold D. Kester^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Web of Science)

Abstract

For the two-treatment two-period crossover trial with a dichotomous outcome measure a simple and straightforward analysis is proposed: compute the treatment difference for each of the treatment sequences AB and BA, and then average over the sequence groups. The mean difference is used in the statistical test and in the computation of the 95 per cent confidence interval. The method is generalized to the case of a crossover trial including more than two treatments.

Original language	English
Pages (from-to)	193-198
Journal	Statistics in Medicine
Volume	29
Issue number	2
DOIs	https://doi.org/10.1002/sim.3771
Publication status	Published - 30 Jan 2010

Keywords

crossover trial
dichotomous outcome
two-treatment
confidence interval
sample size

Access to Document

10.1002/sim.3771

Cite this

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