A simple analysis of a simple crossover trial with a dichotomous outcome measure

Hubert Schouten, Arnold D. Kester*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Web of Science)


For the two-treatment two-period crossover trial with a dichotomous outcome measure a simple and straightforward analysis is proposed: compute the treatment difference for each of the treatment sequences AB and BA, and then average over the sequence groups. The mean difference is used in the statistical test and in the computation of the 95 per cent confidence interval. The method is generalized to the case of a crossover trial including more than two treatments.
Original languageEnglish
Pages (from-to)193-198
JournalStatistics in Medicine
Issue number2
Publication statusPublished - 30 Jan 2010


  • crossover trial
  • dichotomous outcome
  • two-treatment
  • confidence interval
  • sample size

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