A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

Dan Chen; Therese Truong; Valerie Gaborieau; Graham Byrnes; Amelie Chabrier; Shu-Chun Chuang; Andrew F. Olshan; Mark C. Weissler; Jingchun Luo; Marjorie Romkes; Shama Buch; Tomoko Nukui; Silvia Franceschi; Rolando Herrero; Renato Talamini; Karl T. Kelsey; Brock Christensen; Michael D. McClean; Martin Lacko; Johannes J. Manni; Wilbert H. M. Peters; Jan Lubinski; Joanna Trubicka; Marcin Lener; Joshua E. Muscat; Philip Lazarus; Qingyi Wei; Erich M. Sturgis; Zuo-Feng Zhang; Shen-Chih Chang; Renyi Wang; Stephen M. Schwartz; Chu Chen; Simone Benhamou; Pagona Lagiou; Ivana Holcatov; Lorenzo Richiardi; Kristina Kjaerheim; Antonio Agudo; Xavier Castellsague; Tatiana V. Macfarlane; Luigi Barzan; Cristina Canova; Nalin S. Thakker; David I. Conway; Ariana Znaor; Claire M. Healy; Wolfgang Ahrens; David Zaridze; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Eleonora Fabianova; Alexandru Bucur; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Maria Paula Curado; Sergio Koifman; Ana M. Menezes; Victor Wuensch-Filho; Jose Eluf-Neto; Leticia Fernandez; Stefania Boccia; Mia Hashibe; Richard B. Hayes; Paolo Boffetta; Paul Brennan; James D. Mckay

doi:10.1158/1055-9965.EPI-10-1008

A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

Dan Chen, Therese Truong, Valerie Gaborieau, Graham Byrnes, Amelie Chabrier, Shu-Chun Chuang, Andrew F. Olshan, Mark C. Weissler, Jingchun Luo, Marjorie Romkes, Shama Buch, Tomoko Nukui, Silvia Franceschi, Rolando Herrero, Renato Talamini, Karl T. Kelsey, Brock Christensen, Michael D. McClean, Martin Lacko, Johannes J. ManniWilbert H. M. Peters, Jan Lubinski, Joanna Trubicka, Marcin Lener, Joshua E. Muscat, Philip Lazarus, Qingyi Wei, Erich M. Sturgis, Zuo-Feng Zhang, Shen-Chih Chang, Renyi Wang, Stephen M. Schwartz, Chu Chen, Simone Benhamou, Pagona Lagiou, Ivana Holcatov, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsague, Tatiana V. Macfarlane, Luigi Barzan, Cristina Canova, Nalin S. Thakker, David I. Conway, Ariana Znaor, Claire M. Healy, Wolfgang Ahrens, David Zaridze, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana M. Menezes, Victor Wuensch-Filho, Jose Eluf-Neto, Leticia Fernandez, Stefania Boccia, Mia Hashibe, Richard B. Hayes, Paolo Boffetta, Paul Brennan, James D. Mckay^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P-het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 x 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P-het = 6 x 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P-het = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658-64.

Original language	English
Pages (from-to)	658-664
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	20
Issue number	4
DOIs	https://doi.org/10.1158/1055-9965.EPI-10-1008
Publication status	Published - Apr 2011

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10.1158/1055-9965.EPI-10-1008

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Chen, D., Truong, T., Gaborieau, V., Byrnes, G., Chabrier, A., Chuang, S.-C., Olshan, A. F., Weissler, M. C., Luo, J., Romkes, M., Buch, S., Nukui, T., Franceschi, S., Herrero, R., Talamini, R., Kelsey, K. T., Christensen, B., McClean, M. D., Lacko, M., ... Mckay, J. D. (2011). A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers. Cancer Epidemiology Biomarkers & Prevention, 20(4), 658-664. https://doi.org/10.1158/1055-9965.EPI-10-1008

@article{243c34c99f3e4a6f93b8524dffa6b658,

title = "A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers",

abstract = "Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P-het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 x 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P-het = 6 x 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P-het = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658-64. ",

author = "Dan Chen and Therese Truong and Valerie Gaborieau and Graham Byrnes and Amelie Chabrier and Shu-Chun Chuang and Olshan, {Andrew F.} and Weissler, {Mark C.} and Jingchun Luo and Marjorie Romkes and Shama Buch and Tomoko Nukui and Silvia Franceschi and Rolando Herrero and Renato Talamini and Kelsey, {Karl T.} and Brock Christensen and McClean, {Michael D.} and Martin Lacko and Manni, {Johannes J.} and Peters, {Wilbert H. M.} and Jan Lubinski and Joanna Trubicka and Marcin Lener and Muscat, {Joshua E.} and Philip Lazarus and Qingyi Wei and Sturgis, {Erich M.} and Zuo-Feng Zhang and Shen-Chih Chang and Renyi Wang and Schwartz, {Stephen M.} and Chu Chen and Simone Benhamou and Pagona Lagiou and Ivana Holcatov and Lorenzo Richiardi and Kristina Kjaerheim and Antonio Agudo and Xavier Castellsague and Macfarlane, {Tatiana V.} and Luigi Barzan and Cristina Canova and Thakker, {Nalin S.} and Conway, {David I.} and Ariana Znaor and Healy, {Claire M.} and Wolfgang Ahrens and David Zaridze and Neonila Szeszenia-Dabrowska and Jolanta Lissowska and Eleonora Fabianova and Alexandru Bucur and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Curado, {Maria Paula} and Sergio Koifman and Menezes, {Ana M.} and Victor Wuensch-Filho and Jose Eluf-Neto and Leticia Fernandez and Stefania Boccia and Mia Hashibe and Hayes, {Richard B.} and Paolo Boffetta and Paul Brennan and Mckay, {James D.}",

year = "2011",

month = apr,

doi = "10.1158/1055-9965.EPI-10-1008",

language = "English",

volume = "20",

pages = "658--664",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "4",

}

Chen, D, Truong, T, Gaborieau, V, Byrnes, G, Chabrier, A, Chuang, S-C, Olshan, AF, Weissler, MC, Luo, J, Romkes, M, Buch, S, Nukui, T, Franceschi, S, Herrero, R, Talamini, R, Kelsey, KT, Christensen, B, McClean, MD, Lacko, M, Manni, JJ, Peters, WHM, Lubinski, J, Trubicka, J, Lener, M, Muscat, JE, Lazarus, P, Wei, Q, Sturgis, EM, Zhang, Z-F, Chang, S-C, Wang, R, Schwartz, SM, Chen, C, Benhamou, S, Lagiou, P, Holcatov, I, Richiardi, L, Kjaerheim, K, Agudo, A, Castellsague, X, Macfarlane, TV, Barzan, L, Canova, C, Thakker, NS, Conway, DI, Znaor, A, Healy, CM, Ahrens, W, Zaridze, D, Szeszenia-Dabrowska, N, Lissowska, J, Fabianova, E, Bucur, A, Bencko, V, Foretova, L, Janout, V, Curado, MP, Koifman, S, Menezes, AM, Wuensch-Filho, V, Eluf-Neto, J, Fernandez, L, Boccia, S, Hashibe, M, Hayes, RB, Boffetta, P, Brennan, P & Mckay, JD 2011, 'A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers', Cancer Epidemiology Biomarkers & Prevention, vol. 20, no. 4, pp. 658-664. https://doi.org/10.1158/1055-9965.EPI-10-1008

TY - JOUR

T1 - A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

AU - Chen, Dan

AU - Truong, Therese

AU - Gaborieau, Valerie

AU - Byrnes, Graham

AU - Chabrier, Amelie

AU - Chuang, Shu-Chun

AU - Olshan, Andrew F.

AU - Weissler, Mark C.

AU - Luo, Jingchun

AU - Romkes, Marjorie

AU - Buch, Shama

AU - Nukui, Tomoko

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Talamini, Renato

AU - Kelsey, Karl T.

AU - Christensen, Brock

AU - McClean, Michael D.

AU - Lacko, Martin

AU - Manni, Johannes J.

AU - Peters, Wilbert H. M.

AU - Lubinski, Jan

AU - Trubicka, Joanna

AU - Lener, Marcin

AU - Muscat, Joshua E.

AU - Lazarus, Philip

AU - Wei, Qingyi

AU - Sturgis, Erich M.

AU - Zhang, Zuo-Feng

AU - Chang, Shen-Chih

AU - Wang, Renyi

AU - Schwartz, Stephen M.

AU - Chen, Chu

AU - Benhamou, Simone

AU - Lagiou, Pagona

AU - Holcatov, Ivana

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Agudo, Antonio

AU - Castellsague, Xavier

AU - Macfarlane, Tatiana V.

AU - Barzan, Luigi

AU - Canova, Cristina

AU - Thakker, Nalin S.

AU - Conway, David I.

AU - Znaor, Ariana

AU - Healy, Claire M.

AU - Ahrens, Wolfgang

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Fabianova, Eleonora

AU - Bucur, Alexandru

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Curado, Maria Paula

AU - Koifman, Sergio

AU - Menezes, Ana M.

AU - Wuensch-Filho, Victor

AU - Eluf-Neto, Jose

AU - Fernandez, Leticia

AU - Boccia, Stefania

AU - Hashibe, Mia

AU - Hayes, Richard B.

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Mckay, James D.

PY - 2011/4

Y1 - 2011/4

N2 - Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P-het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 x 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P-het = 6 x 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P-het = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658-64.

AB - Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P-het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 x 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P-het = 6 x 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P-het = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658-64.

U2 - 10.1158/1055-9965.EPI-10-1008

DO - 10.1158/1055-9965.EPI-10-1008

M3 - Article

C2 - 21335511

SN - 1055-9965

VL - 20

SP - 658

EP - 664

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 4

ER -