A role of active brown adipose tissue in cancer cachexia?

E. Beijer, J. Schoenmakers, G. Vijgen, F. Kessels, A.M. Dingemans, P. Schrauwen, E. Wouters, W. van Marken Lichtenbelt, J. Teule, B. Brans

Research output: Contribution to journalArticleAcademic

2 Citations (Scopus)

Abstract

Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and socalled brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using 18F-fluorodeoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.
Original languageEnglish
Pages (from-to)88-94
JournalOncology Reviews
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012

Cite this

Beijer, E. ; Schoenmakers, J. ; Vijgen, G. ; Kessels, F. ; Dingemans, A.M. ; Schrauwen, P. ; Wouters, E. ; van Marken Lichtenbelt, W. ; Teule, J. ; Brans, B. / A role of active brown adipose tissue in cancer cachexia?. In: Oncology Reviews. 2012 ; Vol. 6, No. 1. pp. 88-94.
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abstract = "Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and socalled brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using 18F-fluorodeoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.",
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A role of active brown adipose tissue in cancer cachexia? / Beijer, E.; Schoenmakers, J.; Vijgen, G.; Kessels, F.; Dingemans, A.M.; Schrauwen, P.; Wouters, E.; van Marken Lichtenbelt, W.; Teule, J.; Brans, B.

In: Oncology Reviews, Vol. 6, No. 1, 01.01.2012, p. 88-94.

Research output: Contribution to journalArticleAcademic

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