A Prominent Couple: the TMPRSS2:ERG Gene Fusion in Aggressive Prostate Cancer

Leonie Ratz

Research output: ThesisDoctoral ThesisInternal

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Abstract

Prostate cancer is the most common type of cancer in men. This type of cancer often develops slowly and has a low mortality rate, but it can also present in more aggressive forms. It is unclear which genetic abnormalities influence the progression of prostate cancer. A fusion of two genes (TMPRSS2:ERG) are detected in half of all prostate cancers. Using a cell culture model in which TMPRSS2:ERG is expressed under antibiotic control, this dissertation examined the molecular changes caused by this gene fusion. Our results reveal that this fusion is paired with aggressive changes in the prostate cancer cell. With these findings, we hope to contribute to improved risk assessment and new treatment methods for prostate cancer patients.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Ramaekers, Frans, Supervisor
  • Sültmann, H., Supervisor, External person
  • Klauck, Sabine M., Advisor, External person
  • Altevogt, P., Advisor, External person
Award date15 Dec 2017
Place of PublicationMaastricht
Publisher
Print ISBNs9789461597762
DOIs
Publication statusPublished - 2017

Keywords

  • aggressive prostate cancer
  • gene fusion

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