A Prominent Couple: the TMPRSS2:ERG Gene Fusion in Aggressive Prostate Cancer

Leonie Ratz

doi:10.26481/dis.20171215lr

A Prominent Couple: the TMPRSS2:ERG Gene Fusion in Aggressive Prostate Cancer

Leonie Ratz

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Prostate cancer is the most common type of cancer in men. This type of cancer often develops slowly and has a low mortality rate, but it can also present in more aggressive forms. It is unclear which genetic abnormalities influence the progression of prostate cancer. A fusion of two genes (TMPRSS2:ERG) are detected in half of all prostate cancers. Using a cell culture model in which TMPRSS2:ERG is expressed under antibiotic control, this dissertation examined the molecular changes caused by this gene fusion. Our results reveal that this fusion is paired with aggressive changes in the prostate cancer cell. With these findings, we hope to contribute to improved risk assessment and new treatment methods for prostate cancer patients.

Original language	English
Awarding Institution	Maastricht University
Supervisors/Advisors	Ramaekers, Frans, Supervisor Sültmann, H., Supervisor, External person Klauck, Sabine M., Co-Supervisor, External person Altevogt, P., Co-Supervisor, External person
Award date	15 Dec 2017
Place of Publication	Maastricht
Publisher	Datawyse / Universitaire Pers Maastricht
Print ISBNs	9789461597762
DOIs	https://doi.org/10.26481/dis.20171215lr
Publication status	Published - 2017

Keywords

aggressive prostate cancer
gene fusion

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10.26481/dis.20171215lr

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Cite this

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title = "A Prominent Couple: the TMPRSS2:ERG Gene Fusion in Aggressive Prostate Cancer ",

abstract = "Prostate cancer is the most common type of cancer in men. This type of cancer often develops slowly and has a low mortality rate, but it can also present in more aggressive forms. It is unclear which genetic abnormalities influence the progression of prostate cancer. A fusion of two genes (TMPRSS2:ERG) are detected in half of all prostate cancers. Using a cell culture model in which TMPRSS2:ERG is expressed under antibiotic control, this dissertation examined the molecular changes caused by this gene fusion. Our results reveal that this fusion is paired with aggressive changes in the prostate cancer cell. With these findings, we hope to contribute to improved risk assessment and new treatment methods for prostate cancer patients. ",

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AB - Prostate cancer is the most common type of cancer in men. This type of cancer often develops slowly and has a low mortality rate, but it can also present in more aggressive forms. It is unclear which genetic abnormalities influence the progression of prostate cancer. A fusion of two genes (TMPRSS2:ERG) are detected in half of all prostate cancers. Using a cell culture model in which TMPRSS2:ERG is expressed under antibiotic control, this dissertation examined the molecular changes caused by this gene fusion. Our results reveal that this fusion is paired with aggressive changes in the prostate cancer cell. With these findings, we hope to contribute to improved risk assessment and new treatment methods for prostate cancer patients.

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ER -

A Prominent Couple: the TMPRSS2:ERG Gene Fusion in Aggressive Prostate Cancer

Abstract

Keywords

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