A practical cytological approach to the diagnosis of breast-implant associated anaplastic large cell lymphoma

Ellis Barbe; Mintsje de Boer; Daphne de Jong

doi:10.1111/cyt.12678

A practical cytological approach to the diagnosis of breast-implant associated anaplastic large cell lymphoma

Ellis Barbe, Mintsje de Boer, Daphne de Jong^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The role of cytopathology in malignant lymphoma is largely restricted to primary screening in patients with lymphadenopathy of unknown causes and evaluation of relapse and transformation during follow-up of patients with known and fully classified malignant lymphoma. Few lymphoma diagnoses fully rely on cytology, although breast-implant associated anaplastic large cell lymphoma is currently the centre of clinical attention. Due to the major attention both in the medical and lay media for the recently substantiated high lymphoma risk in women with breast implants, cytopathology departments now frequently receive seroma fluid aspirates with this specific differential diagnostic consideration. In this review, we discuss clinico-pathological aspects of breast-implant associated anaplastic large cell lymphoma from a cytological point of view and provide guidelines for the processing of aspirates in daily practice and strategies for diagnostic work-up of seroma fluids.

Original language	English
Pages (from-to)	363-369
Number of pages	7
Journal	Cytopathology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1111/cyt.12678
Publication status	Published - Jul 2019

Keywords

breast-implant associated anaplastic large cell lymphoma
cytological aspirate
periprosthetic seroma
CLASSIFICATION
CYTOPATHOLOGY

Access to Document

10.1111/cyt.12678

Cite this

@article{0df21849942c4a37851190840dbc37cd,

title = "A practical cytological approach to the diagnosis of breast-implant associated anaplastic large cell lymphoma",

abstract = "The role of cytopathology in malignant lymphoma is largely restricted to primary screening in patients with lymphadenopathy of unknown causes and evaluation of relapse and transformation during follow-up of patients with known and fully classified malignant lymphoma. Few lymphoma diagnoses fully rely on cytology, although breast-implant associated anaplastic large cell lymphoma is currently the centre of clinical attention. Due to the major attention both in the medical and lay media for the recently substantiated high lymphoma risk in women with breast implants, cytopathology departments now frequently receive seroma fluid aspirates with this specific differential diagnostic consideration. In this review, we discuss clinico-pathological aspects of breast-implant associated anaplastic large cell lymphoma from a cytological point of view and provide guidelines for the processing of aspirates in daily practice and strategies for diagnostic work-up of seroma fluids.",

keywords = "breast-implant associated anaplastic large cell lymphoma, cytological aspirate, periprosthetic seroma, CLASSIFICATION, CYTOPATHOLOGY",

author = "Ellis Barbe and {de Boer}, Mintsje and {de Jong}, Daphne",

note = "Funding Information: We thank Dr Esther van den Broek, PALGA Foundation, Houten, the Netherlands, for providing data on the frequency of reported seroma aspiration procedures within and outside the breast implant setting and Dr Babette Becherer, Dutch Institute for Clinical Auditing, Leiden, the Netherlands for sharing preliminary data from the Dutch Breast Implant Registry. Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons Ltd",

year = "2019",

month = jul,

doi = "10.1111/cyt.12678",

language = "English",

volume = "30",

pages = "363--369",

journal = "Cytopathology",

issn = "0956-5507",

publisher = "Wiley",

number = "4",

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TY - JOUR

T1 - A practical cytological approach to the diagnosis of breast-implant associated anaplastic large cell lymphoma

AU - Barbe, Ellis

AU - de Boer, Mintsje

AU - de Jong, Daphne

N1 - Funding Information: We thank Dr Esther van den Broek, PALGA Foundation, Houten, the Netherlands, for providing data on the frequency of reported seroma aspiration procedures within and outside the breast implant setting and Dr Babette Becherer, Dutch Institute for Clinical Auditing, Leiden, the Netherlands for sharing preliminary data from the Dutch Breast Implant Registry. Publisher Copyright: © 2019 John Wiley & Sons Ltd

PY - 2019/7

Y1 - 2019/7

N2 - The role of cytopathology in malignant lymphoma is largely restricted to primary screening in patients with lymphadenopathy of unknown causes and evaluation of relapse and transformation during follow-up of patients with known and fully classified malignant lymphoma. Few lymphoma diagnoses fully rely on cytology, although breast-implant associated anaplastic large cell lymphoma is currently the centre of clinical attention. Due to the major attention both in the medical and lay media for the recently substantiated high lymphoma risk in women with breast implants, cytopathology departments now frequently receive seroma fluid aspirates with this specific differential diagnostic consideration. In this review, we discuss clinico-pathological aspects of breast-implant associated anaplastic large cell lymphoma from a cytological point of view and provide guidelines for the processing of aspirates in daily practice and strategies for diagnostic work-up of seroma fluids.

AB - The role of cytopathology in malignant lymphoma is largely restricted to primary screening in patients with lymphadenopathy of unknown causes and evaluation of relapse and transformation during follow-up of patients with known and fully classified malignant lymphoma. Few lymphoma diagnoses fully rely on cytology, although breast-implant associated anaplastic large cell lymphoma is currently the centre of clinical attention. Due to the major attention both in the medical and lay media for the recently substantiated high lymphoma risk in women with breast implants, cytopathology departments now frequently receive seroma fluid aspirates with this specific differential diagnostic consideration. In this review, we discuss clinico-pathological aspects of breast-implant associated anaplastic large cell lymphoma from a cytological point of view and provide guidelines for the processing of aspirates in daily practice and strategies for diagnostic work-up of seroma fluids.

KW - breast-implant associated anaplastic large cell lymphoma

KW - cytological aspirate

KW - periprosthetic seroma

KW - CLASSIFICATION

KW - CYTOPATHOLOGY

U2 - 10.1111/cyt.12678

DO - 10.1111/cyt.12678

M3 - (Systematic) Review article

SN - 0956-5507

VL - 30

SP - 363

EP - 369

JO - Cytopathology

JF - Cytopathology

IS - 4

ER -