A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., "weaving") while driving at a blood alcohol concentration of 0.5 g/L

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Abstract

Introduction
The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of lateral position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study.
Methods
The present study pooled data of 182 participants from nine placebo-controlled crossover studies who performed the highway driving test, while their BAC was at or just below the legal limit for drivers (i.e., 0.5 g/L).
Results
Overall, mean SDLP increased with 2.5 cm (95% CI 2.0–2.9 cm). Equivalence testing showed that the clinical relevance criterion value of 2.4 cm fell well within the 95% CI in each individual study. Gender did not affect alcohol-induced changes in SDLP.
Discussion
These results demonstrate the robustness and validity of the clinical relevance criterion for SDLP as measured during on-the-road driving.
Original languageEnglish
Pages (from-to)837–844
Number of pages8
JournalPsychopharmacology
Volume234
Issue number5
Early online date9 Jan 2017
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Alcohol
  • On-the-road driving
  • Standard deviation of lateral position
  • Clinical relevance
  • DRIVER IMPAIRMENT
  • PERFORMANCE
  • PSYCHOMOTOR
  • CETIRIZINE
  • FEMALES
  • MALES

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