A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

Jeanine M. Genkinger; Donna Spiegelman; Kristin E. Anderson; Leslie Bernstein; Piet A. van den Brandt; Eugenia E. Calle; Dallas R. English; Aaron R. Folsom; Jo L. Freudenheim; Charles S. Fuchs; Graham G. Giles; Edward Giovannucci; Pamela L. Horn-Ross; Susanna C. Larsson; Michael Leitzmann; Satu Mannisto; James R. Marshall; Anthony B. Miller; Alpa V. Patel; Thomas E. Rohan; Rachael Z. Stolzenberg-Solomon; Bas A. J. Verhage; Jarmo Virtamo; Bradley J. Willcox; Alicja Wolk; Regina G. Ziegler; Stephanie A. Smith-Warner

doi:10.1002/ijc.25794

A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

Jeanine M. Genkinger^*, Donna Spiegelman, Kristin E. Anderson, Leslie Bernstein, Piet A. van den Brandt, Eugenia E. Calle, Dallas R. English, Aaron R. Folsom, Jo L. Freudenheim, Charles S. Fuchs, Graham G. Giles, Edward Giovannucci, Pamela L. Horn-Ross, Susanna C. Larsson, Michael Leitzmann, Satu Mannisto, James R. Marshall, Anthony B. Miller, Alpa V. Patel, Thomas E. RohanRachael Z. Stolzenberg-Solomon, Bas A. J. Verhage, Jarmo Virtamo, Bradley J. Willcox, Alicja Wolk, Regina G. Ziegler, Stephanie A. Smith-Warner

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI <25 kg/m(2)) and not obese at baseline (BMI <30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.

Original language	English
Pages (from-to)	1708-1717
Journal	International Journal of Cancer
Volume	129
Issue number	7
DOIs	https://doi.org/10.1002/ijc.25794
Publication status	Published - 1 Oct 2011

Keywords

pancreatic cancer
anthropometry
pooled analysis
deceased

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10.1002/ijc.25794

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Genkinger, J. M., Spiegelman, D., Anderson, K. E., Bernstein, L., van den Brandt, P. A., Calle, E. E., English, D. R., Folsom, A. R., Freudenheim, J. L., Fuchs, C. S., Giles, G. G., Giovannucci, E., Horn-Ross, P. L., Larsson, S. C., Leitzmann, M., Mannisto, S., Marshall, J. R., Miller, A. B., Patel, A. V., ... Smith-Warner, S. A. (2011). A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. International Journal of Cancer, 129(7), 1708-1717. https://doi.org/10.1002/ijc.25794

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title = "A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk",

abstract = "Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI <25 kg/m(2)) and not obese at baseline (BMI <30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.",

keywords = "pancreatic cancer, anthropometry, pooled analysis, deceased",

author = "Genkinger, {Jeanine M.} and Donna Spiegelman and Anderson, {Kristin E.} and Leslie Bernstein and {van den Brandt}, {Piet A.} and Calle, {Eugenia E.} and English, {Dallas R.} and Folsom, {Aaron R.} and Freudenheim, {Jo L.} and Fuchs, {Charles S.} and Giles, {Graham G.} and Edward Giovannucci and Horn-Ross, {Pamela L.} and Larsson, {Susanna C.} and Michael Leitzmann and Satu Mannisto and Marshall, {James R.} and Miller, {Anthony B.} and Patel, {Alpa V.} and Rohan, {Thomas E.} and Stolzenberg-Solomon, {Rachael Z.} and Verhage, {Bas A. J.} and Jarmo Virtamo and Willcox, {Bradley J.} and Alicja Wolk and Ziegler, {Regina G.} and Smith-Warner, {Stephanie A.}",

year = "2011",

month = oct,

day = "1",

doi = "10.1002/ijc.25794",

language = "English",

volume = "129",

pages = "1708--1717",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley",

number = "7",

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Genkinger, JM, Spiegelman, D, Anderson, KE, Bernstein, L, van den Brandt, PA, Calle, EE, English, DR, Folsom, AR, Freudenheim, JL, Fuchs, CS, Giles, GG, Giovannucci, E, Horn-Ross, PL, Larsson, SC, Leitzmann, M, Mannisto, S, Marshall, JR, Miller, AB, Patel, AV, Rohan, TE, Stolzenberg-Solomon, RZ, Verhage, BAJ, Virtamo, J, Willcox, BJ, Wolk, A, Ziegler, RG & Smith-Warner, SA 2011, 'A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk', International Journal of Cancer, vol. 129, no. 7, pp. 1708-1717. https://doi.org/10.1002/ijc.25794

TY - JOUR

T1 - A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

AU - Genkinger, Jeanine M.

AU - Spiegelman, Donna

AU - Anderson, Kristin E.

AU - Bernstein, Leslie

AU - van den Brandt, Piet A.

AU - Calle, Eugenia E.

AU - English, Dallas R.

AU - Folsom, Aaron R.

AU - Freudenheim, Jo L.

AU - Fuchs, Charles S.

AU - Giles, Graham G.

AU - Giovannucci, Edward

AU - Horn-Ross, Pamela L.

AU - Larsson, Susanna C.

AU - Leitzmann, Michael

AU - Mannisto, Satu

AU - Marshall, James R.

AU - Miller, Anthony B.

AU - Patel, Alpa V.

AU - Rohan, Thomas E.

AU - Stolzenberg-Solomon, Rachael Z.

AU - Verhage, Bas A. J.

AU - Virtamo, Jarmo

AU - Willcox, Bradley J.

AU - Wolk, Alicja

AU - Ziegler, Regina G.

AU - Smith-Warner, Stephanie A.

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI <25 kg/m(2)) and not obese at baseline (BMI <30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.

AB - Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI <25 kg/m(2)) and not obese at baseline (BMI <30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.

KW - pancreatic cancer

KW - anthropometry

KW - pooled analysis

KW - deceased

U2 - 10.1002/ijc.25794

DO - 10.1002/ijc.25794

M3 - Article

C2 - 21105029

SN - 0020-7136

VL - 129

SP - 1708

EP - 1717

JO - International Journal of Cancer

JF - International Journal of Cancer

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ER -