A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains

Siri Ranlund, Stella Calafato, Johan H. Thygesen, Kuang Lin, Wiepke Cahn, Benedicto Crespo-Facorro, Sonja M. C. Zwarte, Alvaro Diez, Marta Di Forti, Conrad Iyegbe, Assen Jablensky, Rebecca Jones, Mei-Hua Hall, Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Marco PicchioniDiana P. Prata, Dan Rujescu, Katja Schulze, Madiha Shaikh, Timothea Toulopoulou, Neeltje van Haren, Jim van Os, Evangelos Vassos, Muriel Walshe, Cathryn Lewis, Robin M. Murray, John Powell, Elvira Bramon, GROUP; PEIC; WTCCC2

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)21-34
Number of pages14
JournalAmerican Journal of Medical Genetics Part B-neuropsychiatric Genetics
Volume177
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • bipolar disorder
  • cognition
  • EEG
  • schizophrenia
  • single nucleotide polymorphism (SNP)
  • GENOME-WIDE ASSOCIATION
  • EVENT-RELATED POTENTIALS
  • UNAFFECTED 1ST-DEGREE RELATIVES
  • EDINBURGH HIGH-RISK
  • BIPOLAR DISORDER
  • WORKING-MEMORY
  • PSYCHIATRIC-DISORDERS
  • GENETIC OVERLAP
  • MAUDSLEY FAMILY
  • WHITE-MATTER
  • Humans
  • Family/psychology
  • Genetic Predisposition to Disease/genetics
  • Male
  • Polymorphism, Single Nucleotide/genetics
  • Psychotic Disorders/genetics
  • Adult
  • Female
  • Event-Related Potentials, P300
  • Endophenotypes/blood
  • Schizophrenia/genetics
  • European Continental Ancestry Group/genetics
  • Europe
  • Risk Factors
  • Brain/physiology
  • Multifactorial Inheritance/genetics
  • Bipolar Disorder/genetics
  • Neuropsychological Tests
  • Cognition/physiology
  • Australia

Cite this

Ranlund, S., Calafato, S., Thygesen, J. H., Lin, K., Cahn, W., Crespo-Facorro, B., Zwarte, S. M. C., Diez, A., Di Forti, M., Iyegbe, C., Jablensky, A., Jones, R., Hall, M-H., Kahn, R., Kalaydjieva, L., Kravariti, E., McDonald, C., McIntosh, A. M., McQuillin, A., ... GROUP; PEIC; WTCCC2 (2018). A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains. American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 177(1), 21-34. https://doi.org/10.1002/ajmg.b.32581