A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Vanessa Baier, Henrik Cordes, Christoph Thiel, Jose Castell, Ulf P. Neumann, Lars M. Blank, Lars Kuepfer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number1192
Number of pages13
JournalFrontiers in physiology
Volume10
DOIs
Publication statusPublished - 27 Sep 2019

Keywords

  • PBPK
  • computational modelling
  • DILI
  • bile acids
  • BRIC type 2
  • cholestasis
  • ENTEROHEPATIC CIRCULATION
  • INTRAHEPATIC CHOLESTASIS
  • PHARMACOKINETIC MODEL
  • LIVER
  • DIAGNOSIS
  • TRANSPORTERS
  • SIMULATION
  • EXPRESSION
  • BIOMARKERS
  • KINETICS

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