A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO-101 in Patients With Advanced Solid Tumors

F. E. Stuurman; Martijn P. Lolkema; Alwin D. R. Huitema; P. M. M. B. Soetekouw; Hilde Rosing; L. Rolfe; P. Kaur; Jos H. Beijnen; H. van Tinteren; E.E. Voest; Jan H. M. Schellens

doi:10.1002/jcph.108

A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO-101 in Patients With Advanced Solid Tumors

F. E. Stuurman^*, Martijn P. Lolkema, Alwin D. R. Huitema, P. M. M. B. Soetekouw, Hilde Rosing, L. Rolfe, P. Kaur, Jos H. Beijnen, H. van Tinteren, E.E. Voest, Jan H. M. Schellens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	878-883
Journal	Journal of Clinical Pharmacology
Volume	53
Issue number	8
DOIs	https://doi.org/10.1002/jcph.108
Publication status	Published - Aug 2013

Keywords

gemcitabine
CO-101
CP-4126
bioequivalence
QT
QTc intervals
dFdC
dFdU
phase 1
lipid
phospholipids
cancer
formulation
infusion

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10.1002/jcph.108

Cite this

Stuurman, F. E., Lolkema, M. P., Huitema, A. D. R., Soetekouw, P. M. M. B., Rosing, H., Rolfe, L., Kaur, P., Beijnen, J. H., van Tinteren, H., Voest, E. E., & Schellens, J. H. M. (2013). A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO-101 in Patients With Advanced Solid Tumors. Journal of Clinical Pharmacology, 53(8), 878-883. https://doi.org/10.1002/jcph.108

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title = "A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO-101 in Patients With Advanced Solid Tumors",

keywords = "gemcitabine, CO-101, CP-4126, bioequivalence, QT, QTc intervals, dFdC, dFdU, phase 1, lipid, phospholipids, cancer, formulation, infusion",

author = "Stuurman, {F. E.} and Lolkema, {Martijn P.} and Huitema, {Alwin D. R.} and Soetekouw, {P. M. M. B.} and Hilde Rosing and L. Rolfe and P. Kaur and Beijnen, {Jos H.} and {van Tinteren}, H. and E.E. Voest and Schellens, {Jan H. M.}",

year = "2013",

month = aug,

doi = "10.1002/jcph.108",

language = "English",

volume = "53",

pages = "878--883",

journal = "Journal of Clinical Pharmacology",

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Stuurman, FE, Lolkema, MP, Huitema, ADR, Soetekouw, PMMB, Rosing, H, Rolfe, L, Kaur, P, Beijnen, JH, van Tinteren, H, Voest, EE & Schellens, JHM 2013, 'A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO-101 in Patients With Advanced Solid Tumors', Journal of Clinical Pharmacology, vol. 53, no. 8, pp. 878-883. https://doi.org/10.1002/jcph.108

TY - JOUR

T1 - A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO-101 in Patients With Advanced Solid Tumors

AU - Stuurman, F. E.

AU - Lolkema, Martijn P.

AU - Huitema, Alwin D. R.

AU - Soetekouw, P. M. M. B.

AU - Rosing, Hilde

AU - Rolfe, L.

AU - Kaur, P.

AU - Beijnen, Jos H.

AU - van Tinteren, H.

AU - Voest, E.E.

AU - Schellens, Jan H. M.

PY - 2013/8

Y1 - 2013/8

KW - gemcitabine

KW - CO-101

KW - CP-4126

KW - bioequivalence

KW - QT

KW - QTc intervals

KW - dFdC

KW - dFdU

KW - phase 1

KW - lipid

KW - phospholipids

KW - cancer

KW - formulation

KW - infusion

U2 - 10.1002/jcph.108

DO - 10.1002/jcph.108

M3 - Article

SN - 0091-2700

VL - 53

SP - 878

EP - 883

JO - Journal of Clinical Pharmacology

JF - Journal of Clinical Pharmacology

IS - 8

ER -