A patient with a rare metabolic disease and myo-inositol administration leading to a new treatment for epilepsy

Gerard T. Berry; E. Naomi Vos; Didem Demirbas; William Brucker; Allissia Gilmartin; Maria K. Lehtinen; Edward Yang; Sanjay P. Prabhu; Jie Chen; Xiaoping Huang; Wanshu Qi; Michael J. Bennett; Robin L. Haynes; Lance Rodan; Annapurna Poduri; Phillip L. Pearl; Alexander Rotenberg; Miao He; M. Estela Rubio-Gozalbo

doi:10.1016/j.ymgme.2026.109871

A patient with a rare metabolic disease and myo-inositol administration leading to a new treatment for epilepsy

Gerard T. Berry^*
, E. Naomi Vos
, Didem Demirbas
, William Brucker
, Allissia Gilmartin
, Maria K. Lehtinen
, Edward Yang
, Sanjay P. Prabhu
, Jie Chen
, Xiaoping Huang
, Wanshu Qi
, Michael J. Bennett
, Robin L. Haynes
, Lance Rodan
, Annapurna Poduri
, Phillip L. Pearl
, Alexander Rotenberg
, Miao He
, M. Estela Rubio-Gozalbo

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic › peer-review

Original language	English
Article number	109871
Number of pages	3
Journal	Molecular Genetics and Metabolism
Volume	148
Issue number	2
DOIs	https://doi.org/10.1016/j.ymgme.2026.109871
Publication status	Published - 1 Jun 2026

Keywords

Myo-inositol
Developmental and epileptic encephalopathy
Congenital disorders of glycosylation
Defects of glycosylphosphatidylinositol (GPI) anchor synthesis
KAINIC ACID
INOSITOL
BRAIN
SMIT1
GENE
GALACTITOL
SLC5A3

Access to Document

10.1016/j.ymgme.2026.109871

Cite this

Berry, G. T., Vos, E. N., Demirbas, D., Brucker, W., Gilmartin, A., Lehtinen, M. K., Yang, E., Prabhu, S. P., Chen, J., Huang, X., Qi, W., Bennett, M. J., Haynes, R. L., Rodan, L., Poduri, A., Pearl, P. L., Rotenberg, A., He, M., & Rubio-Gozalbo, M. E. (2026). A patient with a rare metabolic disease and myo-inositol administration leading to a new treatment for epilepsy. Molecular Genetics and Metabolism, 148(2), Article 109871. https://doi.org/10.1016/j.ymgme.2026.109871

@article{50db16c3f63d4a66934ec3c442e2d23e,

title = "A patient with a rare metabolic disease and myo-inositol administration leading to a new treatment for epilepsy",

keywords = "Myo-inositol, Developmental and epileptic encephalopathy, Congenital disorders of glycosylation, Defects of glycosylphosphatidylinositol (GPI) anchor synthesis, KAINIC ACID, INOSITOL, BRAIN, SMIT1, GENE, GALACTITOL, SLC5A3",

author = "Berry, \{Gerard T.\} and Vos, \{E. Naomi\} and Didem Demirbas and William Brucker and Allissia Gilmartin and Lehtinen, \{Maria K.\} and Edward Yang and Prabhu, \{Sanjay P.\} and Jie Chen and Xiaoping Huang and Wanshu Qi and Bennett, \{Michael J.\} and Haynes, \{Robin L.\} and Lance Rodan and Annapurna Poduri and Pearl, \{Phillip L.\} and Alexander Rotenberg and Miao He and Rubio-Gozalbo, \{M. Estela\}",

year = "2026",

month = jun,

day = "1",

doi = "10.1016/j.ymgme.2026.109871",

language = "English",

volume = "148",

journal = "Molecular Genetics and Metabolism",

issn = "1096-7192",

publisher = "Academic Press Inc.",

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}

Berry, GT, Vos, EN, Demirbas, D, Brucker, W, Gilmartin, A, Lehtinen, MK, Yang, E, Prabhu, SP, Chen, J, Huang, X, Qi, W, Bennett, MJ, Haynes, RL, Rodan, L, Poduri, A, Pearl, PL, Rotenberg, A, He, M & Rubio-Gozalbo, ME 2026, 'A patient with a rare metabolic disease and myo-inositol administration leading to a new treatment for epilepsy', Molecular Genetics and Metabolism, vol. 148, no. 2, 109871. https://doi.org/10.1016/j.ymgme.2026.109871

TY - JOUR

T1 - A patient with a rare metabolic disease and myo-inositol administration leading to a new treatment for epilepsy

AU - Berry, Gerard T.

AU - Vos, E. Naomi

AU - Demirbas, Didem

AU - Brucker, William

AU - Gilmartin, Allissia

AU - Lehtinen, Maria K.

AU - Yang, Edward

AU - Prabhu, Sanjay P.

AU - Chen, Jie

AU - Huang, Xiaoping

AU - Qi, Wanshu

AU - Bennett, Michael J.

AU - Haynes, Robin L.

AU - Rodan, Lance

AU - Poduri, Annapurna

AU - Pearl, Phillip L.

AU - Rotenberg, Alexander

AU - He, Miao

AU - Rubio-Gozalbo, M. Estela

PY - 2026/6/1

Y1 - 2026/6/1

KW - Myo-inositol

KW - Developmental and epileptic encephalopathy

KW - Congenital disorders of glycosylation

KW - Defects of glycosylphosphatidylinositol (GPI) anchor synthesis

KW - KAINIC ACID

KW - INOSITOL

KW - BRAIN

KW - SMIT1

KW - GENE

KW - GALACTITOL

KW - SLC5A3

U2 - 10.1016/j.ymgme.2026.109871

DO - 10.1016/j.ymgme.2026.109871

M3 - Editorial

SN - 1096-7192

VL - 148

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

IS - 2

M1 - 109871

ER -