A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels

Harshvardhan Rolyan; Shujun Liu; Janneke G. J. Hoeijmakers; Karin Faber; Ingemar S. J. Merkies; Giuseppe Lauria; Joel A. Black; Stephen G. Waxman

doi:10.1177/1744806916674472

A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels

Harshvardhan Rolyan, Shujun Liu, Janneke G. J. Hoeijmakers, Karin Faber, Ingemar S. J. Merkies, Giuseppe Lauria, Joel A. Black, Stephen G. Waxman

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1-13
Journal	Molecular Pain
Volume	12
DOIs	https://doi.org/10.1177/1744806916674472
Publication status	Published - 7 Nov 2016

Keywords

ATP
axon degeneration
mitochondria
peripheral neuropathy
reactive oxygen species
sodium-calcium exchanger
voltage-gated sodium channel

Access to Document

10.1177/1744806916674472

Cite this

Rolyan, H., Liu, S., Hoeijmakers, J. G. J., Faber, K., Merkies, I. S. J., Lauria, G., Black, J. A., & Waxman, S. G. (2016). A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels. Molecular Pain, 12, 1-13. https://doi.org/10.1177/1744806916674472

Rolyan, Harshvardhan ; Liu, Shujun ; Hoeijmakers, Janneke G. J. ; Faber, Karin ; Merkies, Ingemar S. J. ; Lauria, Giuseppe ; Black, Joel A. ; Waxman, Stephen G. / A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels. In: Molecular Pain. 2016 ; Vol. 12. pp. 1-13.

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title = "A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels",

keywords = "ATP, axon degeneration, mitochondria, peripheral neuropathy, reactive oxygen species, sodium-calcium exchanger, voltage-gated sodium channel",

author = "Harshvardhan Rolyan and Shujun Liu and Hoeijmakers, {Janneke G. J.} and Karin Faber and Merkies, {Ingemar S. J.} and Giuseppe Lauria and Black, {Joel A.} and Waxman, {Stephen G.}",

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A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels. / Rolyan, Harshvardhan; Liu, Shujun; Hoeijmakers, Janneke G. J.; Faber, Karin; Merkies, Ingemar S. J.; Lauria, Giuseppe; Black, Joel A.; Waxman, Stephen G.

In: Molecular Pain, Vol. 12, 07.11.2016, p. 1-13.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Liu, Shujun

AU - Hoeijmakers, Janneke G. J.

AU - Faber, Karin

AU - Merkies, Ingemar S. J.

AU - Lauria, Giuseppe

AU - Black, Joel A.

AU - Waxman, Stephen G.

PY - 2016/11/7

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KW - ATP

KW - axon degeneration

KW - mitochondria

KW - peripheral neuropathy

KW - reactive oxygen species

KW - sodium-calcium exchanger

KW - voltage-gated sodium channel

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JF - Molecular Pain

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