A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides

Gaston J. J. Richelle, Marcel Schmidt, Hans Ippel, Tilman M. Hackeng, Jan H. van Maarseveen, Timo Nuijens, Peter Timmerman

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1934-1938
Number of pages5
JournalChembiochem
Volume19
Issue number18
DOIs
Publication statusPublished - 17 Sep 2018

Keywords

  • cyclization
  • enzymes
  • peptides
  • structure-activity
  • relationships
  • synthesis design
  • CROSS-LINKING
  • BH3 HELIX
  • THERAPEUTICS
  • CYCLIZATION
  • CYCLOTIDES
  • INHIBITOR
  • SCAFFOLDS
  • DESIGN

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