A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides

Gaston J. J. Richelle, Marcel Schmidt, Hans Ippel, Tilman M. Hackeng, Jan H. van Maarseveen, Timo Nuijens*, Peter Timmerman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1934-1938
Number of pages5
JournalChembiochem
Volume19
Issue number18
DOIs
Publication statusPublished - 17 Sep 2018

Keywords

  • cyclization
  • enzymes
  • peptides
  • structure-activity
  • relationships
  • synthesis design
  • CROSS-LINKING
  • BH3 HELIX
  • THERAPEUTICS
  • CYCLIZATION
  • CYCLOTIDES
  • INHIBITOR
  • SCAFFOLDS
  • DESIGN

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