A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides

Gaston J. J. Richelle; Marcel Schmidt; Hans Ippel; Tilman M. Hackeng; Jan H. van Maarseveen; Timo Nuijens; Peter Timmerman

doi:10.1002/cbic.201800346

A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides

Gaston J. J. Richelle, Marcel Schmidt, Hans Ippel, Tilman M. Hackeng, Jan H. van Maarseveen, Timo Nuijens, Peter Timmerman

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1934-1938
Number of pages	5
Journal	Chembiochem
Volume	19
Issue number	18
DOIs	https://doi.org/10.1002/cbic.201800346
Publication status	Published - 17 Sep 2018

Keywords

cyclization
enzymes
peptides
structure-activity
relationships
synthesis design
CROSS-LINKING
BH3 HELIX
THERAPEUTICS
CYCLIZATION
CYCLOTIDES
INHIBITOR
SCAFFOLDS
DESIGN

Access to Document

10.1002/cbic.201800346

Cite this

Richelle, G. J. J., Schmidt, M., Ippel, H., Hackeng, T. M., van Maarseveen, J. H., Nuijens, T., & Timmerman, P. (2018). A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides. Chembiochem, 19(18), 1934-1938. https://doi.org/10.1002/cbic.201800346

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title = "A One-Pot {"}Triple-C{"} Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides",

keywords = "cyclization, enzymes, peptides, structure-activity, relationships, synthesis design, CROSS-LINKING, BH3 HELIX, THERAPEUTICS, CYCLIZATION, CYCLOTIDES, INHIBITOR, SCAFFOLDS, DESIGN",

author = "Richelle, {Gaston J. J.} and Marcel Schmidt and Hans Ippel and Hackeng, {Tilman M.} and {van Maarseveen}, {Jan H.} and Timo Nuijens and Peter Timmerman",

year = "2018",

month = sep,

day = "17",

doi = "10.1002/cbic.201800346",

language = "English",

volume = "19",

pages = "1934--1938",

journal = "Chembiochem",

issn = "1439-4227",

publisher = "Wiley-VCH Verlag",

number = "18",

}

A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides. / Richelle, Gaston J. J.; Schmidt, Marcel; Ippel, Hans ; Hackeng, Tilman M.; van Maarseveen, Jan H.; Nuijens, Timo; Timmerman, Peter.

In: Chembiochem, Vol. 19, No. 18, 17.09.2018, p. 1934-1938.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides

AU - Richelle, Gaston J. J.

AU - Schmidt, Marcel

AU - Ippel, Hans

AU - Hackeng, Tilman M.

AU - van Maarseveen, Jan H.

AU - Nuijens, Timo

AU - Timmerman, Peter

PY - 2018/9/17

Y1 - 2018/9/17

KW - cyclization

KW - enzymes

KW - peptides

KW - structure-activity

KW - relationships

KW - synthesis design

KW - CROSS-LINKING

KW - BH3 HELIX

KW - THERAPEUTICS

KW - CYCLIZATION

KW - CYCLOTIDES

KW - INHIBITOR

KW - SCAFFOLDS

KW - DESIGN

U2 - 10.1002/cbic.201800346

DO - 10.1002/cbic.201800346

M3 - Article

VL - 19

SP - 1934

EP - 1938

JO - Chembiochem

JF - Chembiochem

SN - 1439-4227

IS - 18

ER -