A novel rectal applicator for contact radiotherapy with HDR Ir-192 sources

Murillo Bellezzo; Gabriel P. Fonseca; An-Sofie Verrijssen; Robert Voncken; Michiel R. Van den Bosch; Helio Yoriyaz; Brigitte Reniers; Maaike Berbee; Evert J. Van Limbergen; Frank Verhaegen

doi:10.1016/j.brachy.2018.07.012

A novel rectal applicator for contact radiotherapy with HDR Ir-192 sources

Murillo Bellezzo, Gabriel P. Fonseca, An-Sofie Verrijssen, Robert Voncken, Michiel R. Van den Bosch, Helio Yoriyaz, Brigitte Reniers, Maaike Berbee, Evert J. Van Limbergen, Frank Verhaegen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate Ir-192 BT sources.

METHODS AND MATERIALS: A cylindrical multichannel BT applicator with lateral shielding was designed by Monte Carlo modeling, validated experimentally with film dosimetry and compared with results found in the literature for the Papillon 50 (P50) contact x-ray radiotherapy device regarding rectoscope dimensions, radiation beam shape, dose fall-off, and treatment time.

RESULTS: The multichannel applicator designed is able to deliver 30 Gy under 13 min with a 20350 U (5 Ci) source. The use of multiple channels and lateral shielding provide a uniform circular treatment surface with 22 mm in diameter. The resulting dose fall-off is slightly steeper (maximum difference of 5%) than the one generated by the P50 device with the 22 mm applicator.

CONCLUSIONS: A novel multichannel rectal applicator for contact radiotherapy with high-dose-rate Ir-192 sources that can be integrated with commercially available treatment planning systems was designed to produce a dose distribution similar to the one obtained by the P50 device. (C) 2018 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1037-1044
Number of pages	8
Journal	Brachytherapy
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.brachy.2018.07.012
Publication status	Published - 2018

Keywords

Brachytherapy
Monte Carlo
Contact radiotherapy
Rectal applicator
X-RAY BRACHYTHERAPY
QUALITY-OF-LIFE
RADIATION-THERAPY
MONTE-CARLO
ORGAN PRESERVATION
TECHNICAL NOTE
CANCER
DOSIMETRY
ADENOCARCINOMA
PARAMETERS

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10.1016/j.brachy.2018.07.012

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@article{c98cd7d65c854ace9dd4993e8ffa4135,

title = "A novel rectal applicator for contact radiotherapy with HDR Ir-192 sources",

abstract = "PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate Ir-192 BT sources.METHODS AND MATERIALS: A cylindrical multichannel BT applicator with lateral shielding was designed by Monte Carlo modeling, validated experimentally with film dosimetry and compared with results found in the literature for the Papillon 50 (P50) contact x-ray radiotherapy device regarding rectoscope dimensions, radiation beam shape, dose fall-off, and treatment time.RESULTS: The multichannel applicator designed is able to deliver 30 Gy under 13 min with a 20350 U (5 Ci) source. The use of multiple channels and lateral shielding provide a uniform circular treatment surface with 22 mm in diameter. The resulting dose fall-off is slightly steeper (maximum difference of 5%) than the one generated by the P50 device with the 22 mm applicator.CONCLUSIONS: A novel multichannel rectal applicator for contact radiotherapy with high-dose-rate Ir-192 sources that can be integrated with commercially available treatment planning systems was designed to produce a dose distribution similar to the one obtained by the P50 device. (C) 2018 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.",

keywords = "Brachytherapy, Monte Carlo, Contact radiotherapy, Rectal applicator, X-RAY BRACHYTHERAPY, QUALITY-OF-LIFE, RADIATION-THERAPY, MONTE-CARLO, ORGAN PRESERVATION, TECHNICAL NOTE, CANCER, DOSIMETRY, ADENOCARCINOMA, PARAMETERS",

author = "Murillo Bellezzo and Fonseca, {Gabriel P.} and An-Sofie Verrijssen and Robert Voncken and {Van den Bosch}, {Michiel R.} and Helio Yoriyaz and Brigitte Reniers and Maaike Berbee and {Van Limbergen}, {Evert J.} and Frank Verhaegen",

year = "2018",

doi = "10.1016/j.brachy.2018.07.012",

language = "English",

volume = "17",

pages = "1037--1044",

journal = "Brachytherapy",

issn = "1538-4721",

publisher = "Elsevier Science",

number = "6",

}

TY - JOUR

T1 - A novel rectal applicator for contact radiotherapy with HDR Ir-192 sources

AU - Bellezzo, Murillo

AU - Fonseca, Gabriel P.

AU - Verrijssen, An-Sofie

AU - Voncken, Robert

AU - Van den Bosch, Michiel R.

AU - Yoriyaz, Helio

AU - Reniers, Brigitte

AU - Berbee, Maaike

AU - Van Limbergen, Evert J.

AU - Verhaegen, Frank

PY - 2018

Y1 - 2018

N2 - PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate Ir-192 BT sources.METHODS AND MATERIALS: A cylindrical multichannel BT applicator with lateral shielding was designed by Monte Carlo modeling, validated experimentally with film dosimetry and compared with results found in the literature for the Papillon 50 (P50) contact x-ray radiotherapy device regarding rectoscope dimensions, radiation beam shape, dose fall-off, and treatment time.RESULTS: The multichannel applicator designed is able to deliver 30 Gy under 13 min with a 20350 U (5 Ci) source. The use of multiple channels and lateral shielding provide a uniform circular treatment surface with 22 mm in diameter. The resulting dose fall-off is slightly steeper (maximum difference of 5%) than the one generated by the P50 device with the 22 mm applicator.CONCLUSIONS: A novel multichannel rectal applicator for contact radiotherapy with high-dose-rate Ir-192 sources that can be integrated with commercially available treatment planning systems was designed to produce a dose distribution similar to the one obtained by the P50 device. (C) 2018 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

AB - PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate Ir-192 BT sources.METHODS AND MATERIALS: A cylindrical multichannel BT applicator with lateral shielding was designed by Monte Carlo modeling, validated experimentally with film dosimetry and compared with results found in the literature for the Papillon 50 (P50) contact x-ray radiotherapy device regarding rectoscope dimensions, radiation beam shape, dose fall-off, and treatment time.RESULTS: The multichannel applicator designed is able to deliver 30 Gy under 13 min with a 20350 U (5 Ci) source. The use of multiple channels and lateral shielding provide a uniform circular treatment surface with 22 mm in diameter. The resulting dose fall-off is slightly steeper (maximum difference of 5%) than the one generated by the P50 device with the 22 mm applicator.CONCLUSIONS: A novel multichannel rectal applicator for contact radiotherapy with high-dose-rate Ir-192 sources that can be integrated with commercially available treatment planning systems was designed to produce a dose distribution similar to the one obtained by the P50 device. (C) 2018 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

KW - Brachytherapy

KW - Monte Carlo

KW - Contact radiotherapy

KW - Rectal applicator

KW - X-RAY BRACHYTHERAPY

KW - QUALITY-OF-LIFE

KW - RADIATION-THERAPY

KW - MONTE-CARLO

KW - ORGAN PRESERVATION

KW - TECHNICAL NOTE

KW - CANCER

KW - DOSIMETRY

KW - ADENOCARCINOMA

KW - PARAMETERS

U2 - 10.1016/j.brachy.2018.07.012

DO - 10.1016/j.brachy.2018.07.012

M3 - Article

C2 - 30122346

SN - 1538-4721

VL - 17

SP - 1037

EP - 1044

JO - Brachytherapy

JF - Brachytherapy

IS - 6

ER -

A novel rectal applicator for contact radiotherapy with HDR Ir-192 sources

Abstract

Keywords

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