A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the "Low Drug Uptake Volume"

Ala Yaromina; Marlies Granzier; Rianne Biemans; Natasja Lieuwes; Wouter van Elmpt; Georgy Shakirin; Ludwig Dubois; Philippe Lambin

doi:10.1016/j.radonc.2017.04.020

A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the "Low Drug Uptake Volume"

Ala Yaromina^*, Marlies Granzier, Rianne Biemans, Natasja Lieuwes, Wouter van Elmpt, Georgy Shakirin, Ludwig Dubois, Philippe Lambin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	513-520
Number of pages	8
Journal	Radiotherapy and Oncology
Volume	124
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2017.04.020
Publication status	Published - Sep 2017
Event	15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology - SWITZERLAND, Switzerland Duration: 17 Jun 2017 → 19 Jun 2017

Keywords

Dose-painting
HX4 PET
Hypoxia-activated prodrug
TH-302
Growth delay
Radiotherapy
Rat rhabdomyosarcoma
SQUAMOUS-CELL CARCINOMA
ACTIVATED PRODRUG TH-302
NECK-CANCER PATIENTS
PHASE-I TRIAL
FRACTIONATED-IRRADIATION
PROGNOSTIC VALUE
LUNG-CANCER
INTERNATIONAL MULTICENTER
LOCAL-CONTROL
NUDE-MICE

Access to Document

10.1016/j.radonc.2017.04.020

Cite this

Yaromina, A., Granzier, M., Biemans, R., Lieuwes, N., van Elmpt, W., Shakirin, G., Dubois, L., & Lambin, P. (2017). A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the "Low Drug Uptake Volume". Radiotherapy and Oncology, 124(3), 513-520. https://doi.org/10.1016/j.radonc.2017.04.020

@article{a60f98a90997433cadd185dddfd6c644,

title = "A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the {"}Low Drug Uptake Volume{"}",

keywords = "Dose-painting, HX4 PET, Hypoxia-activated prodrug, TH-302, Growth delay, Radiotherapy, Rat rhabdomyosarcoma, SQUAMOUS-CELL CARCINOMA, ACTIVATED PRODRUG TH-302, NECK-CANCER PATIENTS, PHASE-I TRIAL, FRACTIONATED-IRRADIATION, PROGNOSTIC VALUE, LUNG-CANCER, INTERNATIONAL MULTICENTER, LOCAL-CONTROL, NUDE-MICE",

author = "Ala Yaromina and Marlies Granzier and Rianne Biemans and Natasja Lieuwes and {van Elmpt}, Wouter and Georgy Shakirin and Ludwig Dubois and Philippe Lambin",

year = "2017",

month = sep,

doi = "10.1016/j.radonc.2017.04.020",

language = "English",

volume = "124",

pages = "513--520",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "3",

note = "15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology ; Conference date: 17-06-2017 Through 19-06-2017",

}

A novel concept for tumour targeting with radiation : Inverse dose-painting or targeting the "Low Drug Uptake Volume". / Yaromina, Ala; Granzier, Marlies; Biemans, Rianne; Lieuwes, Natasja ; van Elmpt, Wouter; Shakirin, Georgy; Dubois, Ludwig ; Lambin, Philippe.

In: Radiotherapy and Oncology, Vol. 124, No. 3, 09.2017, p. 513-520.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A novel concept for tumour targeting with radiation

T2 - 15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology

AU - Yaromina, Ala

AU - Granzier, Marlies

AU - Biemans, Rianne

AU - Lieuwes, Natasja

AU - van Elmpt, Wouter

AU - Shakirin, Georgy

AU - Dubois, Ludwig

AU - Lambin, Philippe

PY - 2017/9

Y1 - 2017/9

KW - Dose-painting

KW - HX4 PET

KW - Hypoxia-activated prodrug

KW - TH-302

KW - Growth delay

KW - Radiotherapy

KW - Rat rhabdomyosarcoma

KW - SQUAMOUS-CELL CARCINOMA

KW - ACTIVATED PRODRUG TH-302

KW - NECK-CANCER PATIENTS

KW - PHASE-I TRIAL

KW - FRACTIONATED-IRRADIATION

KW - PROGNOSTIC VALUE

KW - LUNG-CANCER

KW - INTERNATIONAL MULTICENTER

KW - LOCAL-CONTROL

KW - NUDE-MICE

U2 - 10.1016/j.radonc.2017.04.020

DO - 10.1016/j.radonc.2017.04.020

M3 - Article

VL - 124

SP - 513

EP - 520

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 3

Y2 - 17 June 2017 through 19 June 2017

ER -