A new algorithm in patients with elevated and/or rising prostate-specific antigen level, minor lower urinary tract symptoms, and negative multisite prostate biopsies

Koenraad van Renterghem*, Gommert Van Koeveringe, Ruth Achten, Philip E. V. A. Van Kerrebroeck

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Patients with elevated and/or rising prostate-specific antigen (PSA), minor lower urinary tract symptoms (LUTS), and no evidence for prostate cancer on (multiple) extended prostate biopsies are a regularly encountered problem in urological practice. Even now, patients are seen with no objective explanation of this persistent elevated and/or rising PSA. So far, many strategic proposals have been elaborated and published to deal with this specific population including the use of different PSA derivates; applying different biopsy schemes-strategies-biopsy target imaging; diagnostic use of prostate cancer genes; and many more. In this review, we propose a new algorithm in which an urodynamic evaluation should be included since bladder outlet obstruction (BOO) can be expected. Once BOO is confirmed, a transurethral resection of the prostate (TURP) can be offered to these patients. This procedure will result in subjective and biochemical improvement and allows extensive histological examination. Current literature was reviewed with regard to this specific population. This research was performed using the commercially available Medline online search tools and applying the following search terms: "diagnostic TURP"; "elevated PSA"; and "prostate biopsy". Furthermore, subsequent reference search was executed on retrieved articles.
Original languageEnglish
Pages (from-to)29-38
JournalInternational Urology and Nephrology
Issue number1
Publication statusPublished - Mar 2010


  • Benign prostatic hyperplasia (BPH)
  • Bladder outlet obstruction (BOO)
  • Prostate cancer
  • Transurethral resection of the prostate (TURP)
  • Elevated prostate-specific antigen (PSA)

Cite this